5-(4-chlorophenyl)-2-phenyl-4-thiazoleacetic acid

Base Information

• Chemical Name: 5-(4-chlorophenyl)-2-phenyl-4-thiazoleacetic acid
• CAS No.: 23111-31-1
• Molecular Formula: C₁₇H₁₂ClNO₂S
• Molecular Weight: 329.807
• Mol file: 23111-31-1.mol

Synonyms:5-(4-chlorophenyl)-2-phenyl-4-thiazoleacetic acid

Chemical Property of 5-(4-chlorophenyl)-2-phenyl-4-thiazoleacetic acid

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 5-(4-chlorophenyl)-2-phenyl-4-thiazoleacetic acid

There total 6 articles about 5-(4-chlorophenyl)-2-phenyl-4-thiazoleacetic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

C21H20ClNO2S → 5-(4-chlorophenyl)-2-phenyl-4-thiazoleacetic acid (23111-31-1)

Guidance literature:

With trifluoroacetic acid; In dichloromethane; at 25 ℃; for 3h; Inert atmosphere;

DOI:10.1002/chem.202101256

Reference yield:

C15H9BrClNS → 5-(4-chlorophenyl)-2-phenyl-4-thiazoleacetic acid (23111-31-1)

Guidance literature:

Multi-step reaction with 2 steps

1: tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; XPhos / tetrahydrofuran / 1 h / 65 °C / Schlenk technique; Inert atmosphere

2: trifluoroacetic acid / dichloromethane / 3 h / 25 °C / Inert atmosphere

With tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; trifluoroacetic acid; XPhos; In tetrahydrofuran; dichloromethane;

DOI:10.1002/chem.202101256

Reference yield:

5-bromo-2-phenyl-1,3-thiazole (53715-67-6) → 5-(4-chlorophenyl)-2-phenyl-4-thiazoleacetic acid (23111-31-1)

Guidance literature:

Multi-step reaction with 4 steps

1: lithium diisopropyl amide / tetrahydrofuran / 0.5 h / 0 °C / Schlenk technique; Inert atmosphere

2: tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; tris(para-trifluoromethyl)phenyl phosphine / tetrahydrofuran / 3 h / 80 °C / Schlenk technique; Inert atmosphere

3: tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; XPhos / tetrahydrofuran / 1 h / 65 °C / Schlenk technique; Inert atmosphere

4: trifluoroacetic acid / dichloromethane / 3 h / 25 °C / Inert atmosphere

With tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; trifluoroacetic acid; lithium diisopropyl amide; XPhos; tris(para-trifluoromethyl)phenyl phosphine; In tetrahydrofuran; dichloromethane; 2: |Negishi Coupling;

DOI:10.1002/chem.202101256

upstream raw materials:

5-bromo-2-phenyl-1,3-thiazole

1-Chloro-4-iodobenzene