2-[3-cyano-4-(4-{[6-(3,5-dioxo-10-oxa-4-aza-tricyclo[5.2.1.0^2,6]dec-8-en-4-yl)-hexyl]-propyl-amino}-phenyl)-5,5-dimethyl-5H-furan-2-ylidene]-malononitrile

Base Information

• Chemical Name: 2-[3-cyano-4-(4-{[6-(3,5-dioxo-10-oxa-4-aza-tricyclo[5.2.1.0^2,6]dec-8-en-4-yl)-hexyl]-propyl-amino}-phenyl)-5,5-dimethyl-5H-furan-2-ylidene]-malononitrile
• CAS No.: 913733-36-5
• Molecular Formula: C₃₃H₃₅N₅O₄
• Molecular Weight: 565.672

Synonyms:2-[3-cyano-4-(4-{[6-(3,5-dioxo-10-oxa-4-aza-tricyclo[5.2.1.0^2,6]dec-8-en-4-yl)-hexyl]-propyl-amino}-phenyl)-5,5-dimethyl-5H-furan-2-ylidene]-malononitrile

Chemical Property of 2-[3-cyano-4-(4-{[6-(3,5-dioxo-10-oxa-4-aza-tricyclo[5.2.1.0^2,6]dec-8-en-4-yl)-hexyl]-propyl-amino}-phenyl)-5,5-dimethyl-5H-furan-2-ylidene]-malononitrile

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-[3-cyano-4-(4-{[6-(3,5-dioxo-10-oxa-4-aza-tricyclo[5.2.1.0^2,6]dec-8-en-4-yl)-hexyl]-propyl-amino}-phenyl)-5,5-dimethyl-5H-furan-2-ylidene]-malononitrile

There total 5 articles about 2-[3-cyano-4-(4-{[6-(3,5-dioxo-10-oxa-4-aza-tricyclo[5.2.1.0^2,6]dec-8-en-4-yl)-hexyl]-propyl-amino}-phenyl)-5,5-dimethyl-5H-furan-2-ylidene]-malononitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2-(6-hydroxyhexyl)-3a,4,7,7a-tetrahydro-1H-4,7-epoxyisoindole-1,3(2H)-dione → 2-[3-cyano-4-(4-{[6-(3,5-dioxo-10-oxa-4-aza-tricyclo[5.2.1.02,6]dec-8-en-4-yl)-hexyl]-propyl-amino}-phenyl)-5,5-dimethyl-5H-furan-2-ylidene]-malononitrile (913733-36-5)

Guidance literature:

Multi-step reaction with 3 steps

1: pyridine / 0 °C

2: tetrahydrofuran

3: pyridine; AcOH / 48 h / 20 °C

With pyridine; acetic acid; In tetrahydrofuran;

DOI:10.1016/j.tetlet.2006.07.142

Reference yield:

1,6-hexanediol (629-11-8) → 2-[3-cyano-4-(4-{[6-(3,5-dioxo-10-oxa-4-aza-tricyclo[5.2.1.02,6]dec-8-en-4-yl)-hexyl]-propyl-amino}-phenyl)-5,5-dimethyl-5H-furan-2-ylidene]-malononitrile (913733-36-5)

Guidance literature:

Multi-step reaction with 5 steps

1: 55 percent / pyridine / 0 °C

2: K₂CO₃ / dimethylformamide / 50 °C

3: pyridine / 0 °C

4: tetrahydrofuran

5: pyridine; AcOH / 48 h / 20 °C

With pyridine; potassium carbonate; acetic acid; In tetrahydrofuran; N,N-dimethyl-formamide;

DOI:10.1016/j.tetlet.2006.07.142

Reference yield:

3,6-epoxy-1,2,3,6-tetrahydrophthalimide (6253-28-7,19878-26-3,42074-03-3) → 2-[3-cyano-4-(4-{[6-(3,5-dioxo-10-oxa-4-aza-tricyclo[5.2.1.02,6]dec-8-en-4-yl)-hexyl]-propyl-amino}-phenyl)-5,5-dimethyl-5H-furan-2-ylidene]-malononitrile (913733-36-5)

Guidance literature:

Multi-step reaction with 4 steps

1: K₂CO₃ / dimethylformamide / 50 °C

2: pyridine / 0 °C

3: tetrahydrofuran

4: pyridine; AcOH / 48 h / 20 °C

With pyridine; potassium carbonate; acetic acid; In tetrahydrofuran; N,N-dimethyl-formamide;

DOI:10.1016/j.tetlet.2006.07.142

upstream raw materials:

2-[3-cyano-4-(4-fluorophenyl)-5,5-dimethyl-5H-furan-2-ylidene]malononitrile

3,6-epoxy-1,2,3,6-tetrahydrophthalimide

1,6-hexanediol

(6-hydroxyhexyl)tosylate

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