ethyl 3-bromo-4-(4-fluorophenyl)-4H-thieno[3,2-b]pyrrole-5-carboxylic acid

Base Information

Chemical Name:ethyl 3-bromo-4-(4-fluorophenyl)-4H-thieno[3,2-b]pyrrole-5-carboxylic acid
CAS No.:1450743-07-3
Molecular Formula:C₁₃H₇BrFNO₂S
Molecular Weight:340.172
Hs Code.:

Synonyms:ethyl 3-bromo-4-(4-fluorophenyl)-4H-thieno[3,2-b]pyrrole-5-carboxylic acid

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Chemical Property of ethyl 3-bromo-4-(4-fluorophenyl)-4H-thieno[3,2-b]pyrrole-5-carboxylic acid

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Technology Process of ethyl 3-bromo-4-(4-fluorophenyl)-4H-thieno[3,2-b]pyrrole-5-carboxylic acid

There total 4 articles about ethyl 3-bromo-4-(4-fluorophenyl)-4H-thieno[3,2-b]pyrrole-5-carboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

: 1450743-05-1
ethyl 3-bromo-4-(4-fluorophenyl)-4H-thieno[3,2-b]pyrrole-5-carboxylate

: 1450743-07-3
ethyl 3-bromo-4-(4-fluorophenyl)-4H-thieno[3,2-b]pyrrole-5-carboxylic acid

Guidance literature:: With sodium hydroxide; In tetrahydrofuran; ethanol; at 65 - 75 ℃; for 2.5h;
DOI:10.1016/j.bmc.2013.05.067

Reference yield:

: 934246-45-4
ethyl 2-azido-3-(4-bromo-2-thienyl)acrylate

: 1450743-07-3
ethyl 3-bromo-4-(4-fluorophenyl)-4H-thieno[3,2-b]pyrrole-5-carboxylic acid

Guidance literature:: Multi-step reaction with 3 steps

1: 5,5-dimethyl-1,3-cyclohexadiene / 2 h / 120 °C

2: copper diacetate; triethylamine; pyridine / 21 h / 20 °C / Molecular sieve

3: sodium hydroxide / tetrahydrofuran; ethanol / 2.5 h / 65 - 75 °C

With pyridine; copper diacetate; triethylamine; sodium hydroxide; In tetrahydrofuran; 5,5-dimethyl-1,3-cyclohexadiene; ethanol;
DOI:10.1016/j.bmc.2013.05.067

Reference yield:

: 18791-75-8
4-Bromothiophen-2-aldehyde

: 1450743-07-3
ethyl 3-bromo-4-(4-fluorophenyl)-4H-thieno[3,2-b]pyrrole-5-carboxylic acid

Guidance literature:: Multi-step reaction with 4 steps

1: sodium ethanolate / ethanol / 2.5 h / -10 - 20 °C

2: 5,5-dimethyl-1,3-cyclohexadiene / 2 h / 120 °C

3: copper diacetate; triethylamine; pyridine / 21 h / 20 °C / Molecular sieve

4: sodium hydroxide / tetrahydrofuran; ethanol / 2.5 h / 65 - 75 °C

With pyridine; sodium ethanolate; copper diacetate; triethylamine; sodium hydroxide; In tetrahydrofuran; 5,5-dimethyl-1,3-cyclohexadiene; ethanol;
DOI:10.1016/j.bmc.2013.05.067