sodium 3-[2-(3,4-dimethoxyphenyl)ethyl]-3,4-dihydro-1-(3-hydroxy-4-methoxyphenyl)-8-methoxy-4-oxo-[1]benzopyrano[3,4-b]pyrrol-7-yl sulfate

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Chemical Name:sodium 3-[2-(3,4-dimethoxyphenyl)ethyl]-3,4-dihydro-1-(3-hydroxy-4-methoxyphenyl)-8-methoxy-4-oxo-[1]benzopyrano[3,4-b]pyrrol-7-yl sulfate
CAS No.:1352336-44-7
Molecular Formula:C₂₉H₂₆NO₁₁S*Na
Molecular Weight:619.581
Hs Code.:

Synonyms:sodium 3-[2-(3,4-dimethoxyphenyl)ethyl]-3,4-dihydro-1-(3-hydroxy-4-methoxyphenyl)-8-methoxy-4-oxo-[1]benzopyrano[3,4-b]pyrrol-7-yl sulfate

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Chemical Property of sodium 3-[2-(3,4-dimethoxyphenyl)ethyl]-3,4-dihydro-1-(3-hydroxy-4-methoxyphenyl)-8-methoxy-4-oxo-[1]benzopyrano[3,4-b]pyrrol-7-yl sulfate

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Technology Process of sodium 3-[2-(3,4-dimethoxyphenyl)ethyl]-3,4-dihydro-1-(3-hydroxy-4-methoxyphenyl)-8-methoxy-4-oxo-[1]benzopyrano[3,4-b]pyrrol-7-yl sulfate

There total 23 articles about sodium 3-[2-(3,4-dimethoxyphenyl)ethyl]-3,4-dihydro-1-(3-hydroxy-4-methoxyphenyl)-8-methoxy-4-oxo-[1]benzopyrano[3,4-b]pyrrol-7-yl sulfate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

: 1352336-49-2
3-[2-(3,4-dimethoxyphenyl)ethyl]-3,4-dihydro-1-(3-hydroxy-4-methoxyphenyl)-8-methoxy-4-oxo-[1]benzopyrano[3,4-b]pyrrol-7-yl 2,2,2-trichloroethyl sulfate

: 1352336-44-7
sodium 3-[2-(3,4-dimethoxyphenyl)ethyl]-3,4-dihydro-1-(3-hydroxy-4-methoxyphenyl)-8-methoxy-4-oxo-[1]benzopyrano[3,4-b]pyrrol-7-yl sulfate

Guidance literature:: 3-[2-(3,4-dimethoxyphenyl)ethyl]-3,4-dihydro-1-(3-hydroxy-4-methoxyphenyl)-8-methoxy-4-oxo-[1]benzopyrano[3,4-b]pyrrol-7-yl 2,2,2-trichloroethyl sulfate; With ammonium formate; zinc; In tetrahydrofuran; methanol; at 20 ℃; for 15h;

In methanol; water; ethyl acetate;
DOI:10.1016/j.bmc.2011.10.030

Reference yield:

: 37942-01-1
5-bromo-2-methoxyphenol

: 1352336-44-7
sodium 3-[2-(3,4-dimethoxyphenyl)ethyl]-3,4-dihydro-1-(3-hydroxy-4-methoxyphenyl)-8-methoxy-4-oxo-[1]benzopyrano[3,4-b]pyrrol-7-yl sulfate

Guidance literature:: Multi-step reaction with 11 steps

1.1: potassium carbonate / acetone / 9 h / Inert atmosphere; Reflux

2.1: tert.-butyl lithium / tetrahydrofuran / 1 h / -78 °C / Inert atmosphere

2.2: 2 h / -78 - 20 °C

2.3: pH 3

3.1: dichloromethane / 26 h / 20 °C

4.1: tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate / tetrahydrofuran; water / 3 h / Reflux; Inert atmosphere

5.1: potassium hydroxide / ethanol; water / 2 h / Reflux

6.1: pyridinium p-toluenesulfonate / dichloromethane / 8 h / Reflux

7.1: quinoline; copper(II) oxide / 0.17 h / 220 °C / Inert atmosphere

8.1: palladium 10% on activated carbon; hydrogen / ethyl acetate / 19 h / 20 °C

9.1: dmap; triethylamine / dichloromethane / 10 h / 0 - 20 °C / Inert atmosphere

10.1: hydrogenchloride / methanol / 12 h / 30 °C

11.1: ammonium formate; zinc / tetrahydrofuran; methanol / 15 h / 20 °C

11.2: Amberlite IRC-50 (Na⁺ form)

With quinoline; hydrogenchloride; dmap; tetrakis(triphenylphosphine) palladium⁽⁰⁾; palladium 10% on activated carbon; hydrogen; tert.-butyl lithium; ammonium formate; pyridinium p-toluenesulfonate; sodium carbonate; potassium carbonate; triethylamine; copper(II) oxide; potassium hydroxide; zinc; In tetrahydrofuran; methanol; ethanol; dichloromethane; water; ethyl acetate; acetone; 4.1: Suzuki-Miyaura coupling;
DOI:10.1016/j.bmc.2011.10.030

Reference yield:

: 4-benzyloxy-5-methoxy-2-(methoxymethoxy)phenylboronic acid

: 1352336-44-7
sodium 3-[2-(3,4-dimethoxyphenyl)ethyl]-3,4-dihydro-1-(3-hydroxy-4-methoxyphenyl)-8-methoxy-4-oxo-[1]benzopyrano[3,4-b]pyrrol-7-yl sulfate

Guidance literature:: Multi-step reaction with 11 steps

1.1: tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate / tetrahydrofuran; water / 3 h / Reflux; Inert atmosphere

2.1: hydrogenchloride / methanol / 3 h / 20 °C

3.1: toluene-4-sulfonic acid / dichloromethane / 3.5 h / Reflux

4.1: tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate / tetrahydrofuran; water / 3 h / Reflux; Inert atmosphere

5.1: potassium hydroxide / ethanol; water / 2 h / Reflux

6.1: pyridinium p-toluenesulfonate / dichloromethane / 8 h / Reflux

7.1: quinoline; copper(II) oxide / 0.17 h / 220 °C / Inert atmosphere

8.1: palladium 10% on activated carbon; hydrogen / ethyl acetate / 19 h / 20 °C

9.1: dmap; triethylamine / dichloromethane / 10 h / 0 - 20 °C / Inert atmosphere

10.1: hydrogenchloride / methanol / 12 h / 30 °C

11.1: ammonium formate; zinc / tetrahydrofuran; methanol / 15 h / 20 °C

11.2: Amberlite IRC-50 (Na⁺ form)

With quinoline; hydrogenchloride; dmap; tetrakis(triphenylphosphine) palladium⁽⁰⁾; palladium 10% on activated carbon; hydrogen; ammonium formate; pyridinium p-toluenesulfonate; sodium carbonate; toluene-4-sulfonic acid; triethylamine; copper(II) oxide; potassium hydroxide; zinc; In tetrahydrofuran; methanol; ethanol; dichloromethane; water; ethyl acetate; 1.1: Suzuki-Miyaura coupling / 4.1: Suzuki-Miyaura coupling;
DOI:10.1016/j.bmc.2011.10.030