3-((2R,4aR,9aS)-4a-Methyl-2-phenyl-4a,8,9,9a-tetrahydro-4H-1,3,5-trioxa-benzocyclohepten-6-yl)-propionic acid methyl ester

Base Information

• Chemical Name: 3-((2R,4aR,9aS)-4a-Methyl-2-phenyl-4a,8,9,9a-tetrahydro-4H-1,3,5-trioxa-benzocyclohepten-6-yl)-propionic acid methyl ester
• CAS No.: 439265-01-7
• Molecular Formula: C₁₉H₂₄O₅
• Molecular Weight: 332.397
• Mol file: 439265-01-7.mol

Synonyms:3-((2R,4aR,9aS)-4a-Methyl-2-phenyl-4a,8,9,9a-tetrahydro-4H-1,3,5-trioxa-benzocyclohepten-6-yl)-propionic acid methyl ester

Chemical Property of 3-((2R,4aR,9aS)-4a-Methyl-2-phenyl-4a,8,9,9a-tetrahydro-4H-1,3,5-trioxa-benzocyclohepten-6-yl)-propionic acid methyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 3-((2R,4aR,9aS)-4a-Methyl-2-phenyl-4a,8,9,9a-tetrahydro-4H-1,3,5-trioxa-benzocyclohepten-6-yl)-propionic acid methyl ester

There total 1 articles about 3-((2R,4aR,9aS)-4a-Methyl-2-phenyl-4a,8,9,9a-tetrahydro-4H-1,3,5-trioxa-benzocyclohepten-6-yl)-propionic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

methyl 3-iodopropanoate (5029-66-3) + Trifluoro-methanesulfonic acid (2R,4aR,9aS)-4a-methyl-2-phenyl-4a,8,9,9a-tetrahydro-4H-1,3,5-trioxa-benzocyclohepten-6-yl ester (439265-00-6) → 3-((2R,4aR,9aS)-4a-Methyl-2-phenyl-4a,8,9,9a-tetrahydro-4H-1,3,5-trioxa-benzocyclohepten-6-yl)-propionic acid methyl ester (439265-01-7)

Guidance literature:

methyl 3-iodopropanoate; With copper; zinc; In N,N-dimethyl acetamide; benzene; for 1.5h; Heating;

Trifluoro-methanesulfonic acid (2R,4aR,9aS)-4a-methyl-2-phenyl-4a,8,9,9a-tetrahydro-4H-1,3,5-trioxa-benzocyclohepten-6-yl ester; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In benzene; at 20 ℃; for 0.5h;

DOI:10.1016/S0040-4039(01)00824-3

Reference yield:

3-((2R,4aR,9aS)-4a-Methyl-2-phenyl-4a,8,9,9a-tetrahydro-4H-1,3,5-trioxa-benzocyclohepten-6-yl)-propionic acid methyl ester (439265-01-7) → (2R,4aR,9aS)-6-(3-Hydroxy-propyl)-4a-methyl-2-phenyl-hexahydro-1,3,5-trioxa-benzocyclohepten-7-ol

Guidance literature:

3-((2R,4aR,9aS)-4a-Methyl-2-phenyl-4a,8,9,9a-tetrahydro-4H-1,3,5-trioxa-benzocyclohepten-6-yl)-propionic acid methyl ester; With dimethylsulfide borane complex; In tetrahydrofuran; at 0 - 20 ℃;

With sodium hydroxide; dihydrogen peroxide; In water;

DOI:10.1016/S0040-4039(01)00824-3

Reference yield:

3-((2R,4aR,9aS)-4a-Methyl-2-phenyl-4a,8,9,9a-tetrahydro-4H-1,3,5-trioxa-benzocyclohepten-6-yl)-propionic acid methyl ester (439265-01-7) → (2R,4aR,5aS,9aR,11aS)-4a-Methyl-2-phenyl-octahydro-1,3,5,9-tetraoxa-dibenzo[a,d]cyclohepten-8-one

Guidance literature:

Multi-step reaction with 2 steps

1.1: BH₃*SMe₂ / tetrahydrofuran / 0 - 20 °C

1.2: H₂O₂; NaOH / H₂O

2.1: TEMPO; NaClO; KBr / CH₂Cl₂; H₂O / 0 °C

With 2,2,6,6-tetramethyl-piperidine-N-oxyl; sodium hypochlorite; dimethylsulfide borane complex; potassium bromide; In tetrahydrofuran; dichloromethane; water;

DOI:10.1016/S0040-4039(01)00824-3

upstream raw materials:

methyl 3-iodopropanoate

Trifluoro-methanesulfonic acid (2R,4aR,9aS)-4a-methyl-2-phenyl-4a,8,9,9a-tetrahydro-4H-1,3,5-trioxa-benzocyclohepten-6-yl ester