N-[3-benzyl-4-(4-chlorophenyl)thiazol-2(3H)-ylidene]-phenylamine

Base Information

• Chemical Name: N-[3-benzyl-4-(4-chlorophenyl)thiazol-2(3H)-ylidene]-phenylamine
• CAS No.: 1354258-83-5
• Molecular Formula: C₂₂H₁₇ClN₂S
• Molecular Weight: 376.909
• Mol file: 1354258-83-5.mol

Synonyms:N-[3-benzyl-4-(4-chlorophenyl)thiazol-2(3H)-ylidene]-phenylamine

Chemical Property of N-[3-benzyl-4-(4-chlorophenyl)thiazol-2(3H)-ylidene]-phenylamine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N-[3-benzyl-4-(4-chlorophenyl)thiazol-2(3H)-ylidene]-phenylamine

There total 3 articles about N-[3-benzyl-4-(4-chlorophenyl)thiazol-2(3H)-ylidene]-phenylamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 65.0%

phenyl isothiocyanate (103-72-0) + 4-chlorobenzoylmethyl bromide (536-38-9) + benzylamine (100-46-9) → N-[3-benzyl-4-(4-chlorophenyl)thiazol-2(3H)-ylidene]-phenylamine (1354258-83-5)

Guidance literature:

With triethylamine; In ethanol; for 0.116667h; regioselective reaction; Reflux;

DOI:10.1016/j.tetlet.2011.11.017

Reference yield:

(4-chlorophenyl)ethynyl iodide (89891-82-7) + phenyl isothiocyanate (103-72-0) + benzylamine (100-46-9) → N-[3-benzyl-4-(4-chlorophenyl)thiazol-2(3H)-ylidene]-phenylamine (1354258-83-5)

Guidance literature:

With acetic acid; In water; at 70 ℃; for 1h; regioselective reaction;

DOI:10.1055/s-0035-1560502

Reference yield:

4-n-chlorophenylacetylene (873-73-4) → N-[3-benzyl-4-(4-chlorophenyl)thiazol-2(3H)-ylidene]-phenylamine (1354258-83-5)

Guidance literature:

Multi-step reaction with 2 steps

1: ammonium iodide; dihydrogen peroxide; acetic acid / water / 20 °C

2: acetic acid / water / 1 h / 70 °C

With ammonium iodide; dihydrogen peroxide; acetic acid; In water;

DOI:10.1055/s-0035-1560502

upstream raw materials:

phenyl isothiocyanate

4-chlorobenzoylmethyl bromide

benzylamine

4-n-chlorophenylacetylene