Ethyl-2-methyl-2-[2-chloro-4-(N-(propen-2-yl)aminomethyl)phenoxy]-propanoate

Base Information

• Chemical Name: Ethyl-2-methyl-2-[2-chloro-4-(N-(propen-2-yl)aminomethyl)phenoxy]-propanoate
• CAS No.: 639784-52-4
• Molecular Formula: C₁₆H₂₂ClNO₃
• Molecular Weight: 311.809
• Mol file: 639784-52-4.mol

Synonyms:Ethyl-2-methyl-2-[2-chloro-4-(N-(propen-2-yl)aminomethyl)phenoxy]-propanoate

Chemical Property of Ethyl-2-methyl-2-[2-chloro-4-(N-(propen-2-yl)aminomethyl)phenoxy]-propanoate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of Ethyl-2-methyl-2-[2-chloro-4-(N-(propen-2-yl)aminomethyl)phenoxy]-propanoate

There total 2 articles about Ethyl-2-methyl-2-[2-chloro-4-(N-(propen-2-yl)aminomethyl)phenoxy]-propanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.84%

ETHYL-2-METHYL-2-( (2-CHLORO-4-FORMYL) PHENOXY) PROPANOATE (639784-42-2) → Ethyl-2-methyl-2-[2-chloro-4-(N-(propen-2-yl)aminomethyl)phenoxy]-propanoate (639784-52-4)

Guidance literature:

With sodium triacetoxy borohydride; trifluoroethylamine; In dichloromethane; at 25 ℃; for 1h;

Reference yield:

4-hydroxy-3-chlorobenzaldehyde (2420-16-8) → Ethyl-2-methyl-2-[2-chloro-4-(N-(propen-2-yl)aminomethyl)phenoxy]-propanoate (639784-52-4)

Guidance literature:

Multi-step reaction with 2 steps

1.1: potassium carbonate / acetone / 0.5 h / 25 °C

1.2: 3 h

1.3: 16 h

2.1: sodium triacetoxy borohydride; trifluoroethylamine / dichloromethane / 1 h / 25 °C

With sodium triacetoxy borohydride; trifluoroethylamine; potassium carbonate; In dichloromethane; acetone;

Reference yield: 75.26%

Ethyl-2-methyl-2-[2-chloro-4-(N-(propen-2-yl)aminomethyl)phenoxy]-propanoate (639784-52-4) → Example 37 (639783-69-0)

Guidance literature:

With [ 1-BENZVL-3-(4-TRIFLUOROMETHOXVPHENVL)-5-BROMOMETHYL-PYRAZOLE]; potassium carbonate; for 1h;

upstream raw materials:

ETHYL-2-METHYL-2-( (2-CHLORO-4-FORMYL) PHENOXY) PROPANOATE

4-hydroxy-3-chlorobenzaldehyde

Downstream raw materials:

Example 37

Example 30

2-METHYL-2-[2-CHLORO-4-(((1-METHYL-3-(4-TRIFLUOROMETHYLPHENYL))-PYRAZOL-5-yl) methyl-N-(propen-2-yl)-aminomethyl)phenoxy] propionic acid

: 2-METHYL-2-[2-CHLORO-4-( ( (1-BENZYL-3-(4-TRIFLUOROMETHYLPHENYL))-PYRAZOL-5-Yl) METHYL-N-(PROPEN-2-YL)-AMINOMETHYL) PHENOXY] PROPIONIC acid