4-(1H-indol-1-yl)-N-(3-(methylcarbamoyl)phenyl)piperidine-1-carboxamide

Base Information

Chemical Name:4-(1H-indol-1-yl)-N-(3-(methylcarbamoyl)phenyl)piperidine-1-carboxamide
CAS No.:1443247-54-8
Molecular Formula:C₂₂H₂₄N₄O₂
Molecular Weight:376.458
Hs Code.:

Synonyms:4-(1H-indol-1-yl)-N-(3-(methylcarbamoyl)phenyl)piperidine-1-carboxamide

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Chemical Property of 4-(1H-indol-1-yl)-N-(3-(methylcarbamoyl)phenyl)piperidine-1-carboxamide

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Technology Process of 4-(1H-indol-1-yl)-N-(3-(methylcarbamoyl)phenyl)piperidine-1-carboxamide

There total 7 articles about 4-(1H-indol-1-yl)-N-(3-(methylcarbamoyl)phenyl)piperidine-1-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 795310-69-9
1-piperidin-4-yl-1H-indole hydrochloride

: C₁₅H₁₃N₃O₅

: 1443247-54-8
4-(1H-indol-1-yl)-N-(3-(methylcarbamoyl)phenyl)piperidine-1-carboxamide

Guidance literature:: With triethylamine; In dichloromethane; at 20 ℃; for 3h;
DOI:10.1016/j.bmcl.2013.09.096

Reference yield:

: 795310-69-9
1-piperidin-4-yl-1H-indole hydrochloride

: 32315-10-9
bis(trichloromethyl) carbonate

: 25900-61-2
3-amino-N-methylbenzamide

: 1443247-54-8
4-(1H-indol-1-yl)-N-(3-(methylcarbamoyl)phenyl)piperidine-1-carboxamide

Guidance literature:: bis(trichloromethyl) carbonate; 3-amino-N-methylbenzamide;

1-piperidin-4-yl-1H-indole hydrochloride; With triethylamine; In dichloromethane; at 20 ℃;
DOI:10.1016/j.bmcl.2013.09.096

Reference yield:

: 120-72-9
indole

: 1443247-54-8
4-(1H-indol-1-yl)-N-(3-(methylcarbamoyl)phenyl)piperidine-1-carboxamide

Guidance literature:: Multi-step reaction with 3 steps

1.1: dichloromethane / 1 h / 20 °C

1.2: 24 h / 20 °C

2.1: trifluoroacetic acid / dichloromethane / 3 h / 20 °C

2.2: 0.5 h / 0 - 20 °C

3.2: 20 °C

With trifluoroacetic acid; In dichloromethane;
DOI:10.1016/j.bmcl.2013.09.096