(3S,6R)-2,5-Dimethoxy-6-isopropyl-3-<(4-oxo-1-cyclohexyl)methyl>-3,6-dihydro-1,4-pyrazine

Base Information

Chemical Name:(3S,6R)-2,5-Dimethoxy-6-isopropyl-3-<(4-oxo-1-cyclohexyl)methyl>-3,6-dihydro-1,4-pyrazine
CAS No.:137232-88-3
Molecular Formula:C₁₆H₂₆N₂O₃
Molecular Weight:294.394
Hs Code.:

Synonyms:(3S,6R)-2,5-Dimethoxy-6-isopropyl-3-<(4-oxo-1-cyclohexyl)methyl>-3,6-dihydro-1,4-pyrazine

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Chemical Property of (3S,6R)-2,5-Dimethoxy-6-isopropyl-3-<(4-oxo-1-cyclohexyl)methyl>-3,6-dihydro-1,4-pyrazine

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Technology Process of (3S,6R)-2,5-Dimethoxy-6-isopropyl-3-<(4-oxo-1-cyclohexyl)methyl>-3,6-dihydro-1,4-pyrazine

There total 5 articles about (3S,6R)-2,5-Dimethoxy-6-isopropyl-3-<(4-oxo-1-cyclohexyl)methyl>-3,6-dihydro-1,4-pyrazine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

: 137232-86-1
(3S,6R)-2,5-Dimethoxy-6-isopropyl-3-<(4-oxo-1-cyclohexenyl)methyl>-3,6-dihydro-1,4-pyrazine

: 137232-88-3
(3S,6R)-2,5-Dimethoxy-6-isopropyl-3-<(4-oxo-1-cyclohexyl)methyl>-3,6-dihydro-1,4-pyrazine

Guidance literature:: With hydrogen; palladium on activated charcoal; In ethyl acetate; for 2h; under 2280 Torr;

Reference yield: 66.0%

: 4-((2S,5R)-5-Isopropyl-3,6-dimethoxy-2,5-dihydro-pyrazin-2-ylmethyl)-cyclohexanol

: 137232-88-3
(3S,6R)-2,5-Dimethoxy-6-isopropyl-3-<(4-oxo-1-cyclohexyl)methyl>-3,6-dihydro-1,4-pyrazine

Guidance literature:: With pyridine; chromium(VI) oxide; In dichloromethane; at 23 ℃; for 0.333333h;
DOI:10.1021/jo00089a019

Reference yield:

: 109838-85-9
(2R)-2,5-dihydro-2-isopropyl-3,6-dimethoxypyrazine

: 137232-88-3
(3S,6R)-2,5-Dimethoxy-6-isopropyl-3-<(4-oxo-1-cyclohexyl)methyl>-3,6-dihydro-1,4-pyrazine

Guidance literature:: Multi-step reaction with 2 steps

1: 1.) 1.6 N n-BuLi, CuBr*Me₂S / 1.) THF, -30 deg C, 10 min; -30 deg C, 30 min, 2.) THF, -78 deg C, 1 h

2: 97 percent / H₂ / 10percent Pd/C / ethyl acetate / 4 h / 23 °C / 2280 Torr

With n-butyllithium; copper(I) bromide dimethylsulfide complex; hydrogen; palladium on activated charcoal; In ethyl acetate;
DOI:10.1021/jo00089a019