N-(2-chloroethyl)-4-octylaniline

Base Information

Chemical Name:N-(2-chloroethyl)-4-octylaniline
CAS No.:1260137-21-0
Molecular Formula:C₁₆H₂₆ClN
Molecular Weight:267.842
Hs Code.:

Synonyms:N-(2-chloroethyl)-4-octylaniline

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Chemical Property of N-(2-chloroethyl)-4-octylaniline

Chemical Property:

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Technology Process of N-(2-chloroethyl)-4-octylaniline

There total 5 articles about N-(2-chloroethyl)-4-octylaniline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

: 1260137-20-9
2-chloro-N-(4-octylphenyl)ethanamide

: 1260137-21-0
N-(2-chloroethyl)-4-octylaniline

Guidance literature:: With dimethylsulfide borane complex; In tetrahydrofuran; at 0 - 20 ℃; Inert atmosphere;
DOI:10.1021/jo102066x

Reference yield:

: 629-05-0
n-octyne

: 1260137-21-0
N-(2-chloroethyl)-4-octylaniline

Guidance literature:: Multi-step reaction with 4 steps

1.1: copper(l) iodide; bis-triphenylphosphine-palladium(II) chloride; triethylamine; N-ethyl-N,N-diisopropylamine / acetonitrile / 0.33 h / Inert atmosphere

1.2: 50 °C / Inert atmosphere

2.1: palladium 10% on activated carbon; hydrogen / ethyl acetate / 3 h / 3750.38 Torr

3.1: potassium carbonate / N,N-dimethyl-formamide / 0 - 20 °C

4.1: dimethylsulfide borane complex / tetrahydrofuran / 0 - 20 °C / Inert atmosphere

With bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; dimethylsulfide borane complex; palladium 10% on activated carbon; hydrogen; potassium carbonate; triethylamine; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; ethyl acetate; N,N-dimethyl-formamide; acetonitrile; 1.1: Sonogashira cross-coupling / 1.2: Sonogashira cross-coupling;
DOI:10.1021/jo102066x

Reference yield:

: 586-78-7
para-nitrophenyl bromide

: 1260137-21-0
N-(2-chloroethyl)-4-octylaniline

Guidance literature:: Multi-step reaction with 4 steps

1.1: copper(l) iodide; bis-triphenylphosphine-palladium(II) chloride; triethylamine; N-ethyl-N,N-diisopropylamine / acetonitrile / 0.33 h / Inert atmosphere

1.2: 50 °C / Inert atmosphere

2.1: palladium 10% on activated carbon; hydrogen / ethyl acetate / 3 h / 3750.38 Torr

3.1: potassium carbonate / N,N-dimethyl-formamide / 0 - 20 °C

4.1: dimethylsulfide borane complex / tetrahydrofuran / 0 - 20 °C / Inert atmosphere

With bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; dimethylsulfide borane complex; palladium 10% on activated carbon; hydrogen; potassium carbonate; triethylamine; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; ethyl acetate; N,N-dimethyl-formamide; acetonitrile; 1.1: Sonogashira cross-coupling / 1.2: Sonogashira cross-coupling;
DOI:10.1021/jo102066x