3-(hydroxymethyl)-1-(4-methylbenzyl)-4-propyl-1H-1,2,4-triazol-5(4H)-one

Base Information

• Chemical Name: 3-(hydroxymethyl)-1-(4-methylbenzyl)-4-propyl-1H-1,2,4-triazol-5(4H)-one
• CAS No.: 425674-77-7
• Molecular Formula: C₁₄H₁₉N₃O₂
• Molecular Weight: 261.324

Synonyms:3-(hydroxymethyl)-1-(4-methylbenzyl)-4-propyl-1H-1,2,4-triazol-5(4H)-one

Chemical Property of 3-(hydroxymethyl)-1-(4-methylbenzyl)-4-propyl-1H-1,2,4-triazol-5(4H)-one

Chemical Property:

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Technology Process of 3-(hydroxymethyl)-1-(4-methylbenzyl)-4-propyl-1H-1,2,4-triazol-5(4H)-one

There total 1 articles about 3-(hydroxymethyl)-1-(4-methylbenzyl)-4-propyl-1H-1,2,4-triazol-5(4H)-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

1-(4-methylbenzyl)-4-propyl-3-(trityloxymethyl)-1H-1,2,4-triazol-5(4H)-one (1232162-11-6) → 3-(hydroxymethyl)-1-(4-methylbenzyl)-4-propyl-1H-1,2,4-triazol-5(4H)-one (425674-77-7)

Guidance literature:

With triethylsilane; trifluoroacetic acid; In dichloromethane; at 20 ℃; for 1h; Product distribution / selectivity;

Reference yield: 75.0%

3-(hydroxymethyl)-1-(4-methylbenzyl)-4-propyl-1H-1,2,4-triazol-5(4H)-one (425674-77-7) → 1-(4-methylbenzyl)-5-oxo-4-propyl-4,5-dihydro-1H-1,2,4-triazole-3-carbaldehyde (1232163-14-2)

Guidance literature:

With manganese(IV) oxide; for 16h; Reflux;

Reference yield:

4-(1-tert-butoxy-2-methyl-1-oxopropan-2-yloxy)benzoic acid (950601-81-7) + 3-(hydroxymethyl)-1-(4-methylbenzyl)-4-propyl-1H-1,2,4-triazol-5(4H)-one (425674-77-7) → (1-(4-methylbenzyl)-5-oxo-4-propyl-4,5-dihydro-1H-1,2,4-triazol-3-yl)methyl 4-(1-tert-butoxy-2-methyl-1-oxopropan-2-yloxy)benzoate (1232162-14-9)

Guidance literature:

With dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In N,N-dimethyl-formamide; for 16h;

upstream raw materials:

1-(4-methylbenzyl)-4-propyl-3-(trityloxymethyl)-1H-1,2,4-triazol-5(4H)-one

Downstream raw materials:

(1-(4-methylbenzyl)-5-oxo-4-propyl-4,5-dihydro-1H-1,2,4-triazol-3-yl)methyl 4-(1-tert-butoxy-2-methyl-1-oxopropan-2-yloxy)benzoate

1-(4-methylbenzyl)-5-oxo-4-propyl-4,5-dihydro-1H-1,2,4-triazole-3-carbaldehyde

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