N-(1-(5-chloro-3-(2-chloro-5-fluorophenyl)quinoxalin-2-yl)ethyl)-9H-purin-6-amine

Base Information

Chemical Name:N-(1-(5-chloro-3-(2-chloro-5-fluorophenyl)quinoxalin-2-yl)ethyl)-9H-purin-6-amine
CAS No.:1065480-07-0
Molecular Formula:C₂₁H₁₄Cl₂FN₇
Molecular Weight:454.293
Hs Code.:

Synonyms:N-(1-(5-chloro-3-(2-chloro-5-fluorophenyl)quinoxalin-2-yl)ethyl)-9H-purin-6-amine

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Chemical Property of N-(1-(5-chloro-3-(2-chloro-5-fluorophenyl)quinoxalin-2-yl)ethyl)-9H-purin-6-amine

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Technology Process of N-(1-(5-chloro-3-(2-chloro-5-fluorophenyl)quinoxalin-2-yl)ethyl)-9H-purin-6-amine

There total 11 articles about N-(1-(5-chloro-3-(2-chloro-5-fluorophenyl)quinoxalin-2-yl)ethyl)-9H-purin-6-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.2%

: 1065482-16-7
1-(5-chloro-3-(2-chloro-5-fluorophenyl)quinoxalin-2-yl)ethanamine

: 767-69-1
6-bromopurine

: 1065480-07-0
N-(1-(5-chloro-3-(2-chloro-5-fluorophenyl)quinoxalin-2-yl)ethyl)-9H-purin-6-amine

Guidance literature:: With N-ethyl-N,N-diisopropylamine; In butan-1-ol; at 100 ℃; for 50h;

Reference yield:

: 444666-39-1
(2-chloro-5-fluorophenyl)boronic acid acid

: 1065480-07-0
N-(1-(5-chloro-3-(2-chloro-5-fluorophenyl)quinoxalin-2-yl)ethyl)-9H-purin-6-amine

Guidance literature:: Multi-step reaction with 7 steps

1: sodium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / water; acetonitrile / 3 h / 100 °C

2: 1,3-dibromo-5,5-dimethylimidazolidine-2,4-dione; dibenzoyl peroxide / tetrachloromethane / 22 h / Heating / reflux

3: sodium periodate / N,N-dimethyl-formamide / 3 h / 150 °C

4: tetrahydrofuran; diethyl ether / 5.5 h / 0 - 20 °C

5: di-isopropyl azodicarboxylate; triphenylphosphine / tetrahydrofuran / 6 h / 20 °C

6: hydrazine / ethanol / 0.5 h / Heating / reflux

7: N-ethyl-N,N-diisopropylamine / butan-1-ol / 50 h / 100 °C

With sodium periodate; 1,3-dibromo-5,5-dimethylimidazolidine-2,4-dione; di-isopropyl azodicarboxylate; sodium carbonate; N-ethyl-N,N-diisopropylamine; triphenylphosphine; hydrazine; dibenzoyl peroxide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; tetrachloromethane; diethyl ether; ethanol; water; N,N-dimethyl-formamide; acetonitrile; butan-1-ol;

Reference yield:

: 1065483-00-2
3,5-dichloro-2-methylquinoxaline

: 1065480-07-0
N-(1-(5-chloro-3-(2-chloro-5-fluorophenyl)quinoxalin-2-yl)ethyl)-9H-purin-6-amine

Guidance literature:: Multi-step reaction with 7 steps

1: sodium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / water; acetonitrile / 3 h / 100 °C

2: 1,3-dibromo-5,5-dimethylimidazolidine-2,4-dione; dibenzoyl peroxide / tetrachloromethane / 22 h / Heating / reflux

3: sodium periodate / N,N-dimethyl-formamide / 3 h / 150 °C

4: tetrahydrofuran; diethyl ether / 5.5 h / 0 - 20 °C

5: di-isopropyl azodicarboxylate; triphenylphosphine / tetrahydrofuran / 6 h / 20 °C

6: hydrazine / ethanol / 0.5 h / Heating / reflux

7: N-ethyl-N,N-diisopropylamine / butan-1-ol / 50 h / 100 °C

With sodium periodate; 1,3-dibromo-5,5-dimethylimidazolidine-2,4-dione; di-isopropyl azodicarboxylate; sodium carbonate; N-ethyl-N,N-diisopropylamine; triphenylphosphine; hydrazine; dibenzoyl peroxide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; tetrachloromethane; diethyl ether; ethanol; water; N,N-dimethyl-formamide; acetonitrile; butan-1-ol;