(1-{[1-benzyl-3,3-difluoro-2-oxo-3-(2-oxo-2-piperidin-1-yl-ethylcarbamoyl)-propylcarbamoyl]-methyl}-6-oxo-2-m-tolyl-1,6-dihydro-pyrimidin-5-yl)-carbamic acid benzyl ester

Base Information

Chemical Name:(1-{[1-benzyl-3,3-difluoro-2-oxo-3-(2-oxo-2-piperidin-1-yl-ethylcarbamoyl)-propylcarbamoyl]-methyl}-6-oxo-2-m-tolyl-1,6-dihydro-pyrimidin-5-yl)-carbamic acid benzyl ester
CAS No.:228108-40-5
Molecular Formula:C₃₉H₄₀F₂N₆O₇
Molecular Weight:742.779
Hs Code.:

(1-{[1-benzyl-3,3-difluoro-2-oxo-3-(2-oxo-2-piperidin-1-yl-ethylcarbamoyl)-propylcarbamoyl]-methyl}-6-oxo-2-<i>m</i>-tolyl-1,6-dihydro-pyrimidin-5-yl)-carbamic acid benzyl ester

Synonyms:(1-{[1-benzyl-3,3-difluoro-2-oxo-3-(2-oxo-2-piperidin-1-yl-ethylcarbamoyl)-propylcarbamoyl]-methyl}-6-oxo-2-m-tolyl-1,6-dihydro-pyrimidin-5-yl)-carbamic acid benzyl ester

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Chemical Property of (1-{[1-benzyl-3,3-difluoro-2-oxo-3-(2-oxo-2-piperidin-1-yl-ethylcarbamoyl)-propylcarbamoyl]-methyl}-6-oxo-2-m-tolyl-1,6-dihydro-pyrimidin-5-yl)-carbamic acid benzyl ester

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Technology Process of (1-{[1-benzyl-3,3-difluoro-2-oxo-3-(2-oxo-2-piperidin-1-yl-ethylcarbamoyl)-propylcarbamoyl]-methyl}-6-oxo-2-m-tolyl-1,6-dihydro-pyrimidin-5-yl)-carbamic acid benzyl ester

There total 5 articles about (1-{[1-benzyl-3,3-difluoro-2-oxo-3-(2-oxo-2-piperidin-1-yl-ethylcarbamoyl)-propylcarbamoyl]-methyl}-6-oxo-2-m-tolyl-1,6-dihydro-pyrimidin-5-yl)-carbamic acid benzyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1027834-98-5
(1-{[1-benzyl-3,3-difluoro-2-hydroxy-3-(2-oxo-2-piperidin-1-yl-ethylcarbamoyl)-propylcarbamoyl]-methyl}-6-oxo-2-m-tolyl-1,6-dihydro-pyrimidin-5-yl)-carbamic acid benzyl ester

: 228108-40-5
(1-{[1-benzyl-3,3-difluoro-2-oxo-3-(2-oxo-2-piperidin-1-yl-ethylcarbamoyl)-propylcarbamoyl]-methyl}-6-oxo-2-m-tolyl-1,6-dihydro-pyrimidin-5-yl)-carbamic acid benzyl ester

Guidance literature:: With Dess-Martin periodane; In N,N-dimethyl-formamide; at 20 ℃; for 14h;
DOI:10.1021/jm000497n

Reference yield:

: 59830-60-3,63219-70-5,68474-26-0
N-benzyloxycarbonyl-2-amino-3-phenylpropionaldehyde

: 228108-40-5
(1-{[1-benzyl-3,3-difluoro-2-oxo-3-(2-oxo-2-piperidin-1-yl-ethylcarbamoyl)-propylcarbamoyl]-methyl}-6-oxo-2-m-tolyl-1,6-dihydro-pyrimidin-5-yl)-carbamic acid benzyl ester

Guidance literature:: Multi-step reaction with 5 steps

1: 86 percent / aq. K₂CO₃ / tetrahydrofuran; methanol / 20 °C

2: 3-hydroxybenzotriazole hydrate; 1-[3(dimethylamino)propyl]-3-ethylcarbodiimide hydrochloride / dimethylformamide / 20 °C

3: H₂; 1 N aq. HCl / 10percent Pd/C / methanol / 15 h / 20 °C

4: N-ethylmorpholine; 1-[3(dimethylamino)propyl]-3-ethylcarbodiimide hydrochloride; 3-hydroxybenzotriazole hydrate / dimethylformamide / 16 h / 20 °C

5: Dess-Martin periodinate / dimethylformamide / 14 h / 20 °C

With N-ethylmorpholine;; hydrogenchloride; hydrogen; potassium carbonate; Dess-Martin periodane; 1-hydroxybenzotriazol-hydrate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; 10percent Pd/C; In tetrahydrofuran; methanol; N,N-dimethyl-formamide; 5: Dess-Martin oxidation;
DOI:10.1021/jm000497n

Reference yield:

: 4-benzyl-4-benzyloxycarbonylamino-2,2-difluoro-3-hydroxybutanoic acid

: 228108-40-5
(1-{[1-benzyl-3,3-difluoro-2-oxo-3-(2-oxo-2-piperidin-1-yl-ethylcarbamoyl)-propylcarbamoyl]-methyl}-6-oxo-2-m-tolyl-1,6-dihydro-pyrimidin-5-yl)-carbamic acid benzyl ester

Guidance literature:: Multi-step reaction with 4 steps

1: 3-hydroxybenzotriazole hydrate; 1-[3(dimethylamino)propyl]-3-ethylcarbodiimide hydrochloride / dimethylformamide / 20 °C

2: H₂; 1 N aq. HCl / 10percent Pd/C / methanol / 15 h / 20 °C

3: N-ethylmorpholine; 1-[3(dimethylamino)propyl]-3-ethylcarbodiimide hydrochloride; 3-hydroxybenzotriazole hydrate / dimethylformamide / 16 h / 20 °C

4: Dess-Martin periodinate / dimethylformamide / 14 h / 20 °C

With N-ethylmorpholine;; hydrogenchloride; hydrogen; Dess-Martin periodane; 1-hydroxybenzotriazol-hydrate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; 10percent Pd/C; In methanol; N,N-dimethyl-formamide; 4: Dess-Martin oxidation;
DOI:10.1021/jm000497n