(4aR,4bS,6aR,8R,10aR,10bR,12aR)-4b,5,6,6a,7,8,9,10,10a,10b,12,12a-dodecahydro-2-methoxy-1,1,4a,10a-tetramethyl-8-(phenylmethoxy)chrysene-4,11(1H,4aH)-dione

Base Information

Chemical Name:(4aR,4bS,6aR,8R,10aR,10bR,12aR)-4b,5,6,6a,7,8,9,10,10a,10b,12,12a-dodecahydro-2-methoxy-1,1,4a,10a-tetramethyl-8-(phenylmethoxy)chrysene-4,11(1H,4aH)-dione
CAS No.:652153-22-5
Molecular Formula:C₃₀H₄₀O₄
Molecular Weight:464.645
Hs Code.:

(4aR,4bS,6aR,8R,10aR,10bR,12aR)-4b,5,6,6a,7,8,9,10,10a,10b,12,12a-dodecahydro-2-methoxy-1,1,4a,10a-tetramethyl-8-(phenylmethoxy)chrysene-4,11(1H,4aH)-dione

Synonyms:(4aR,4bS,6aR,8R,10aR,10bR,12aR)-4b,5,6,6a,7,8,9,10,10a,10b,12,12a-dodecahydro-2-methoxy-1,1,4a,10a-tetramethyl-8-(phenylmethoxy)chrysene-4,11(1H,4aH)-dione

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Chemical Property of (4aR,4bS,6aR,8R,10aR,10bR,12aR)-4b,5,6,6a,7,8,9,10,10a,10b,12,12a-dodecahydro-2-methoxy-1,1,4a,10a-tetramethyl-8-(phenylmethoxy)chrysene-4,11(1H,4aH)-dione

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Technology Process of (4aR,4bS,6aR,8R,10aR,10bR,12aR)-4b,5,6,6a,7,8,9,10,10a,10b,12,12a-dodecahydro-2-methoxy-1,1,4a,10a-tetramethyl-8-(phenylmethoxy)chrysene-4,11(1H,4aH)-dione

There total 17 articles about (4aR,4bS,6aR,8R,10aR,10bR,12aR)-4b,5,6,6a,7,8,9,10,10a,10b,12,12a-dodecahydro-2-methoxy-1,1,4a,10a-tetramethyl-8-(phenylmethoxy)chrysene-4,11(1H,4aH)-dione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

: 652153-29-2
Thiocarbonic acid O-((4aR,4bS,6aR,8R,10aR,10bR,12aR)-8-benzyloxy-2-methoxy-1,1,10a-trimethyl-4,11-dioxo-1,4b,5,6,6a,7,8,9,10,10a,10b,11,12,12a-tetradecahydro-4H-chrysen-4a-ylmethyl) ester O-phenyl ester

: 652153-22-5
(4aR,4bS,6aR,8R,10aR,10bR,12aR)-4b,5,6,6a,7,8,9,10,10a,10b,12,12a-dodecahydro-2-methoxy-1,1,4a,10a-tetramethyl-8-(phenylmethoxy)chrysene-4,11(1H,4aH)-dione

Guidance literature:: With 2,2'-azobis(isobutyronitrile); tri-n-butyl-tin hydride; In toluene; for 2h; Heating;
DOI:10.1002/hlca.200390315

Reference yield:

: 81927-55-1
O-benzyl 2,2,2-trichloroacetimidate

: 652153-22-5
(4aR,4bS,6aR,8R,10aR,10bR,12aR)-4b,5,6,6a,7,8,9,10,10a,10b,12,12a-dodecahydro-2-methoxy-1,1,4a,10a-tetramethyl-8-(phenylmethoxy)chrysene-4,11(1H,4aH)-dione

Guidance literature:: Multi-step reaction with 6 steps

1.1: 77 percent / trifluoromethanesulfonic acid / CH₂Cl₂ / 1 h / 0 °C

2.1: 53 percent / LiHMDS / tetrahydrofuran / 0.25 h / -78 °C

3.1: Cs₂CO₃ / ethyl acetate / 96 h / 20 °C

3.2: 70 percent / morpholine; [Pd(PPh₃)4] / tetrahydrofuran / 1 h / 20 °C

4.1: 99 percent / NaBH₄ / tetrahydrofuran; methanol / 1 h / 0 °C

5.1: 80 percent / pyridine / DMAP / CH₂Cl₂ / 16 h

6.1: 99 percent / AIBN; Bu₃SnH / toluene / 2 h / Heating

With pyridine; sodium tetrahydroborate; 2,2'-azobis(isobutyronitrile); trifluorormethanesulfonic acid; tri-n-butyl-tin hydride; caesium carbonate; lithium hexamethyldisilazane; dmap; In tetrahydrofuran; methanol; dichloromethane; ethyl acetate; toluene;
DOI:10.1002/hlca.200390315

Reference yield:

: 652153-25-8
(4aR,6R,8aR)-6-hydroxy-8a-methyloctahydronaphthalen-1(2H)-one

: 652153-22-5
(4aR,4bS,6aR,8R,10aR,10bR,12aR)-4b,5,6,6a,7,8,9,10,10a,10b,12,12a-dodecahydro-2-methoxy-1,1,4a,10a-tetramethyl-8-(phenylmethoxy)chrysene-4,11(1H,4aH)-dione

Guidance literature:: Multi-step reaction with 8 steps

1.1: sodium; NH₃ / -70 °C

1.2: 83 mg / diethyl ether

2.1: formic acid; H₂SO₄

2.2: 47 percent / K₂CO₃ / methanol; H₂O / 1 h

3.1: 77 percent / trifluoromethanesulfonic acid / CH₂Cl₂ / 1 h / 0 °C

4.1: 53 percent / LiHMDS / tetrahydrofuran / 0.25 h / -78 °C

5.1: Cs₂CO₃ / ethyl acetate / 96 h / 20 °C

5.2: 70 percent / morpholine; [Pd(PPh₃)4] / tetrahydrofuran / 1 h / 20 °C

6.1: 99 percent / NaBH₄ / tetrahydrofuran; methanol / 1 h / 0 °C

7.1: 80 percent / pyridine / DMAP / CH₂Cl₂ / 16 h

8.1: 99 percent / AIBN; Bu₃SnH / toluene / 2 h / Heating

With pyridine; sodium tetrahydroborate; formic acid; 2,2'-azobis(isobutyronitrile); trifluorormethanesulfonic acid; sulfuric acid; ammonia; tri-n-butyl-tin hydride; sodium; caesium carbonate; lithium hexamethyldisilazane; dmap; In tetrahydrofuran; methanol; dichloromethane; ethyl acetate; toluene;
DOI:10.1002/hlca.200390315