Technology Process of dibutyl 1,1-difluoro-3-phenylprop-2-ynylphosphonate
There total 3 articles about dibutyl 1,1-difluoro-3-phenylprop-2-ynylphosphonate which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
copper(l) iodide; 1,10-Phenanthroline; potassium tert-butylate; 2,3-dicyano-5,6-dichloro-p-benzoquinone;
In
N,N-dimethyl-formamide;
at -15 ℃;
for 1h;
Inert atmosphere;
DOI:10.1021/ol301113v
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: sodium hexamethyldisilazane / tetrahydrofuran / 0.67 h / 20 °C / Inert atmosphere
2.1: lithium diisopropyl amide / tetrahydrofuran / 0.5 h / -78 °C / Inert atmosphere
2.2: 1 h / Inert atmosphere
3.1: copper(l) iodide; 1,10-Phenanthroline; potassium tert-butylate; 2,3-dicyano-5,6-dichloro-p-benzoquinone / N,N-dimethyl-formamide / 1 h / -15 °C / Inert atmosphere
With
copper(l) iodide; 1,10-Phenanthroline; potassium tert-butylate; sodium hexamethyldisilazane; 2,3-dicyano-5,6-dichloro-p-benzoquinone; lithium diisopropyl amide;
In
tetrahydrofuran; N,N-dimethyl-formamide;
DOI:10.1021/ol301113v
- Guidance literature:
-
Multi-step reaction with 2 steps
1.1: lithium diisopropyl amide / tetrahydrofuran / 0.5 h / -78 °C / Inert atmosphere
1.2: 1 h / Inert atmosphere
2.1: copper(l) iodide; 1,10-Phenanthroline; potassium tert-butylate; 2,3-dicyano-5,6-dichloro-p-benzoquinone / N,N-dimethyl-formamide / 1 h / -15 °C / Inert atmosphere
With
copper(l) iodide; 1,10-Phenanthroline; potassium tert-butylate; 2,3-dicyano-5,6-dichloro-p-benzoquinone; lithium diisopropyl amide;
In
tetrahydrofuran; N,N-dimethyl-formamide;
DOI:10.1021/ol301113v
