N-[5-(2,4-Dioxo-thiazolidin-5-ylmethyl)-2-hydroxy-phenyl]-2-(4-methoxy-phenyl)-acetamide

Base Information

Chemical Name:N-[5-(2,4-Dioxo-thiazolidin-5-ylmethyl)-2-hydroxy-phenyl]-2-(4-methoxy-phenyl)-acetamide
CAS No.:1026364-42-0
Molecular Formula:C₁₉H₁₈N₂O₅S
Molecular Weight:386.428
Hs Code.:

Synonyms:N-[5-(2,4-Dioxo-thiazolidin-5-ylmethyl)-2-hydroxy-phenyl]-2-(4-methoxy-phenyl)-acetamide

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Chemical Property of N-[5-(2,4-Dioxo-thiazolidin-5-ylmethyl)-2-hydroxy-phenyl]-2-(4-methoxy-phenyl)-acetamide

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Technology Process of N-[5-(2,4-Dioxo-thiazolidin-5-ylmethyl)-2-hydroxy-phenyl]-2-(4-methoxy-phenyl)-acetamide

There total 5 articles about N-[5-(2,4-Dioxo-thiazolidin-5-ylmethyl)-2-hydroxy-phenyl]-2-(4-methoxy-phenyl)-acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 621-44-3
3-nitro-L-tyrosine

: 1026364-42-0
N-[5-(2,4-Dioxo-thiazolidin-5-ylmethyl)-2-hydroxy-phenyl]-2-(4-methoxy-phenyl)-acetamide

Guidance literature:: Multi-step reaction with 5 steps

1: aq. NaNO₂, KBr, aq. 3 N H₂SO₄ / 0.17 h

2: AcONa / ethanol / 3 h / Heating

3: aq. HCl / 2-methoxy-ethanol / 4 h / Heating

4: 96 percent / H₂ / 10percent Pd/C / tetrahydrofuran; methanol / 8 h / 760 Torr

5: DCC / tetrahydrofuran; dimethylformamide

With hydrogenchloride; sulfuric acid; hydrogen; sodium acetate; dicyclohexyl-carbodiimide; potassium bromide; sodium nitrite; palladium on activated charcoal; In tetrahydrofuran; methanol; ethanol; 2-methoxy-ethanol; N,N-dimethyl-formamide;
DOI:10.1248/cpb.45.1984

Reference yield:

: 118383-65-6
2-bromo-3-(4-hydroxy-3-nitrophenyl)propionic acid

: 1026364-42-0
N-[5-(2,4-Dioxo-thiazolidin-5-ylmethyl)-2-hydroxy-phenyl]-2-(4-methoxy-phenyl)-acetamide

Guidance literature:: Multi-step reaction with 4 steps

1: AcONa / ethanol / 3 h / Heating

2: aq. HCl / 2-methoxy-ethanol / 4 h / Heating

3: 96 percent / H₂ / 10percent Pd/C / tetrahydrofuran; methanol / 8 h / 760 Torr

4: DCC / tetrahydrofuran; dimethylformamide

With hydrogenchloride; hydrogen; sodium acetate; dicyclohexyl-carbodiimide; palladium on activated charcoal; In tetrahydrofuran; methanol; ethanol; 2-methoxy-ethanol; N,N-dimethyl-formamide;
DOI:10.1248/cpb.45.1984

Reference yield:

: 118383-66-7
5-(4-hydroxy-3-nitrobenzyl)-2-imino-4-oxothiazolidine

: 1026364-42-0
N-[5-(2,4-Dioxo-thiazolidin-5-ylmethyl)-2-hydroxy-phenyl]-2-(4-methoxy-phenyl)-acetamide

Guidance literature:: Multi-step reaction with 3 steps

1: aq. HCl / 2-methoxy-ethanol / 4 h / Heating

2: 96 percent / H₂ / 10percent Pd/C / tetrahydrofuran; methanol / 8 h / 760 Torr

3: DCC / tetrahydrofuran; dimethylformamide

With hydrogenchloride; hydrogen; dicyclohexyl-carbodiimide; palladium on activated charcoal; In tetrahydrofuran; methanol; 2-methoxy-ethanol; N,N-dimethyl-formamide;
DOI:10.1248/cpb.45.1984