(R)-1-(4-Benzyloxy-3-hydroxymethyl-phenyl)-2-[6-(4-phenyl-butoxy)-hexylamino]-ethanol

Base Information

Chemical Name:(R)-1-(4-Benzyloxy-3-hydroxymethyl-phenyl)-2-[6-(4-phenyl-butoxy)-hexylamino]-ethanol
CAS No.:444809-33-0
Molecular Formula:C₃₂H₄₃NO₄
Molecular Weight:505.698
Hs Code.:

Synonyms:(R)-1-(4-Benzyloxy-3-hydroxymethyl-phenyl)-2-[6-(4-phenyl-butoxy)-hexylamino]-ethanol

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Chemical Property of (R)-1-(4-Benzyloxy-3-hydroxymethyl-phenyl)-2-[6-(4-phenyl-butoxy)-hexylamino]-ethanol

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Technology Process of (R)-1-(4-Benzyloxy-3-hydroxymethyl-phenyl)-2-[6-(4-phenyl-butoxy)-hexylamino]-ethanol

There total 3 articles about (R)-1-(4-Benzyloxy-3-hydroxymethyl-phenyl)-2-[6-(4-phenyl-butoxy)-hexylamino]-ethanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 66.0%

: 97664-58-9
D 2543

: 444809-32-9
((R)-2-Benzyloxy-5-oxiranyl-phenyl)-methanol

: 444809-33-0
(R)-1-(4-Benzyloxy-3-hydroxymethyl-phenyl)-2-[6-(4-phenyl-butoxy)-hexylamino]-ethanol

Guidance literature:: D 2543; With N,O-bis-(trimethylsilyl)-acetamide; In dimethyl sulfoxide; at 20 ℃; for 0.5h;

((R)-2-Benzyloxy-5-oxiranyl-phenyl)-methanol; In dimethyl sulfoxide; at 85 ℃; for 50h;
DOI:10.1016/S0957-4166(02)00010-1

Reference yield:

: 324556-80-1
1-(4-(benzyloxy)-3-(hydroxymethyl)phenyl)-2-bromoethanone

: 444809-33-0
(R)-1-(4-Benzyloxy-3-hydroxymethyl-phenyl)-2-[6-(4-phenyl-butoxy)-hexylamino]-ethanol

Guidance literature:: Multi-step reaction with 3 steps

1.1: sodium lauryl sulphate / acetone / 0.17 h

1.2: Rhodotorula rubra / H₂O / 48 h / 30 °C / pH 7 / 200 rpm

2.1: 67 percent / K₂CO₃ / tetrahydrofuran / 2 h / Heating

3.1: N,O-bis(trimethylsilyl)acetamide / dimethylsulfoxide / 0.5 h / 20 °C

3.2: 66 percent / dimethylsulfoxide / 50 h / 85 °C

With N,O-bis-(trimethylsilyl)-acetamide; sodium dodecyl-sulfate; potassium carbonate; In tetrahydrofuran; dimethyl sulfoxide; acetone;
DOI:10.1016/S0957-4166(02)00010-1

Reference yield:

: 324556-92-5
(R)-(+)-2-bromo-1-(3'-hydroxymethyl-4'-benzyloxyphenyl) ethanol

: 444809-33-0
(R)-1-(4-Benzyloxy-3-hydroxymethyl-phenyl)-2-[6-(4-phenyl-butoxy)-hexylamino]-ethanol

Guidance literature:: Multi-step reaction with 2 steps

1.1: 67 percent / K₂CO₃ / tetrahydrofuran / 2 h / Heating

2.1: N,O-bis(trimethylsilyl)acetamide / dimethylsulfoxide / 0.5 h / 20 °C

2.2: 66 percent / dimethylsulfoxide / 50 h / 85 °C

With N,O-bis-(trimethylsilyl)-acetamide; potassium carbonate; In tetrahydrofuran; dimethyl sulfoxide;
DOI:10.1016/S0957-4166(02)00010-1