2-(3-hydroxy-4-methoxyphenyl)-5-(3,4,5-trimethoxyphenyl)-1,3,4-oxadiazole

Base Information

Chemical Name:2-(3-hydroxy-4-methoxyphenyl)-5-(3,4,5-trimethoxyphenyl)-1,3,4-oxadiazole
CAS No.:1221719-96-5
Molecular Formula:C₁₈H₁₈N₂O₆
Molecular Weight:358.351
Hs Code.:

Synonyms:2-(3-hydroxy-4-methoxyphenyl)-5-(3,4,5-trimethoxyphenyl)-1,3,4-oxadiazole

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 2-(3-hydroxy-4-methoxyphenyl)-5-(3,4,5-trimethoxyphenyl)-1,3,4-oxadiazole

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Technology Process of 2-(3-hydroxy-4-methoxyphenyl)-5-(3,4,5-trimethoxyphenyl)-1,3,4-oxadiazole

There total 6 articles about 2-(3-hydroxy-4-methoxyphenyl)-5-(3,4,5-trimethoxyphenyl)-1,3,4-oxadiazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

: 1251485-57-0
2-(3-(benzyloxy)-4-methoxyphenyl)-5-(3,4,5-trimethoxyphenyl)-1,3,4-oxadiazole

: 1221719-96-5
2-(3-hydroxy-4-methoxyphenyl)-5-(3,4,5-trimethoxyphenyl)-1,3,4-oxadiazole

Guidance literature:: With boron trifluoride diethyl etherate; ethanethiol; In dichloromethane; at 20 ℃;
DOI:10.1016/j.bmc.2010.07.067

Reference yield:

: 1257321-37-1
N'-(3-hydroxy-4-methoxybenzoyl)-3,4,5-trimethoxybenzohydrazide

: 1221719-96-5
2-(3-hydroxy-4-methoxyphenyl)-5-(3,4,5-trimethoxyphenyl)-1,3,4-oxadiazole

Guidance literature:: N'-(3-hydroxy-4-methoxybenzoyl)-3,4,5-trimethoxybenzohydrazide; With triethylamine; p-toluenesulfonyl chloride; In dichloromethane; at 20 ℃;

With water; triethylamine; In methanol; at 20 ℃; for 24h;
DOI:10.1021/np1004278

Reference yield:

: 1916-07-0
3,4,5-trimethoxybenzoic acid methyl ester

: 1221719-96-5
2-(3-hydroxy-4-methoxyphenyl)-5-(3,4,5-trimethoxyphenyl)-1,3,4-oxadiazole

Guidance literature:: Multi-step reaction with 3 steps

1.1: hydrazine hydrate / methanol / 6 h / Reflux

2.1: pyridine / dichloromethane / -20 - 20 °C

3.1: triethylamine; p-toluenesulfonyl chloride / dichloromethane / 20 °C

3.2: 24 h / 20 °C

With pyridine; hydrazine hydrate; triethylamine; p-toluenesulfonyl chloride; In methanol; dichloromethane;
DOI:10.1021/np1004278