(E)-2-cyclohexyl-8-((2-methylstyryl)sulfonyl)-1,3,8-triazaspiro[4.5]dec-1-en-4-one

Base Information

Chemical Name:(E)-2-cyclohexyl-8-((2-methylstyryl)sulfonyl)-1,3,8-triazaspiro[4.5]dec-1-en-4-one
CAS No.:1253916-92-5
Molecular Formula:C₂₂H₂₉N₃O₃S
Molecular Weight:415.557
Hs Code.:

Synonyms:(E)-2-cyclohexyl-8-((2-methylstyryl)sulfonyl)-1,3,8-triazaspiro[4.5]dec-1-en-4-one

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Chemical Property of (E)-2-cyclohexyl-8-((2-methylstyryl)sulfonyl)-1,3,8-triazaspiro[4.5]dec-1-en-4-one

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Technology Process of (E)-2-cyclohexyl-8-((2-methylstyryl)sulfonyl)-1,3,8-triazaspiro[4.5]dec-1-en-4-one

There total 7 articles about (E)-2-cyclohexyl-8-((2-methylstyryl)sulfonyl)-1,3,8-triazaspiro[4.5]dec-1-en-4-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 77.0%

: 95-46-5
2-methylphenyl bromide

: 1253926-01-0
2-cyclohexyl-8-(vinylsulfonyl)-1,3,8-triazaspiro[4.5]dec-1-en-4-one

: 1253916-92-5
(E)-2-cyclohexyl-8-((2-methylstyryl)sulfonyl)-1,3,8-triazaspiro[4.5]dec-1-en-4-one

Guidance literature:: With N-Methyldicyclohexylamine; bis(dibenzylideneacetone)-palladium⁽⁰⁾; tri tert-butylphosphoniumtetrafluoroborate; In 1-methyl-pyrrolidin-2-one; at 110 ℃; for 1.5h; Inert atmosphere;
DOI:10.1021/acs.jmedchem.8b00182

Reference yield:

: 2719-27-9
cyclohexanylcarbonyl chloride

: 1253916-92-5
(E)-2-cyclohexyl-8-((2-methylstyryl)sulfonyl)-1,3,8-triazaspiro[4.5]dec-1-en-4-one

Guidance literature:: Multi-step reaction with 5 steps

1: triethylamine; dmap / dichloromethane / 1 h / 20 °C

2: sodium hydroxide; dihydrogen peroxide / water; ethanol / 4 h / 80 °C

3: hydrogenchloride / 1,4-dioxane / 2 h / 20 °C

4: triethylamine / dichloromethane / 1 h / 0 - 20 °C

5: bis(dibenzylideneacetone)-palladium⁽⁰⁾; tri tert-butylphosphoniumtetrafluoroborate; N-Methyldicyclohexylamine / 1-methyl-pyrrolidin-2-one / 1.5 h / 110 °C / Inert atmosphere

With hydrogenchloride; dmap; N-Methyldicyclohexylamine; dihydrogen peroxide; triethylamine; sodium hydroxide; bis(dibenzylideneacetone)-palladium⁽⁰⁾; tri tert-butylphosphoniumtetrafluoroborate; In 1,4-dioxane; 1-methyl-pyrrolidin-2-one; ethanol; dichloromethane; water; 5: |Heck Reaction;
DOI:10.1021/acs.jmedchem.8b00182

Reference yield:

: tert-butyl 4-cyano-4-(cyclohexanecarboxamido)piperidine-1-carboxylate

: 1253916-92-5
(E)-2-cyclohexyl-8-((2-methylstyryl)sulfonyl)-1,3,8-triazaspiro[4.5]dec-1-en-4-one

Guidance literature:: Multi-step reaction with 4 steps

1: sodium hydroxide; dihydrogen peroxide / water; ethanol / 4 h / 80 °C

2: hydrogenchloride / 1,4-dioxane / 2 h / 20 °C

3: triethylamine / dichloromethane / 1 h / 0 - 20 °C

4: bis(dibenzylideneacetone)-palladium⁽⁰⁾; tri tert-butylphosphoniumtetrafluoroborate; N-Methyldicyclohexylamine / 1-methyl-pyrrolidin-2-one / 1.5 h / 110 °C / Inert atmosphere

With hydrogenchloride; N-Methyldicyclohexylamine; dihydrogen peroxide; triethylamine; sodium hydroxide; bis(dibenzylideneacetone)-palladium⁽⁰⁾; tri tert-butylphosphoniumtetrafluoroborate; In 1,4-dioxane; 1-methyl-pyrrolidin-2-one; ethanol; dichloromethane; water; 4: |Heck Reaction;
DOI:10.1021/acs.jmedchem.8b00182