4-N-(4-fluorophenyl)amino-5-phenyl-7-(2',3'-O-isopropylidene-4'-C-spirocyclopropyl-β-D-erythro-furanosyl)pyrrolo[2,3-d]pyrimidine

Base Information

Chemical Name:4-N-(4-fluorophenyl)amino-5-phenyl-7-(2',3'-O-isopropylidene-4'-C-spirocyclopropyl-β-D-erythro-furanosyl)pyrrolo[2,3-d]pyrimidine
CAS No.:186456-76-8
Molecular Formula:C₂₇H₂₅FN₄O₃
Molecular Weight:472.519
Hs Code.:

Synonyms:4-N-(4-fluorophenyl)amino-5-phenyl-7-(2',3'-O-isopropylidene-4'-C-spirocyclopropyl-β-D-erythro-furanosyl)pyrrolo[2,3-d]pyrimidine

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 4-N-(4-fluorophenyl)amino-5-phenyl-7-(2',3'-O-isopropylidene-4'-C-spirocyclopropyl-β-D-erythro-furanosyl)pyrrolo[2,3-d]pyrimidine

Chemical Property:

Purity/Quality:: 97% ^*data from raw suppliers

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Technology Process of 4-N-(4-fluorophenyl)amino-5-phenyl-7-(2',3'-O-isopropylidene-4'-C-spirocyclopropyl-β-D-erythro-furanosyl)pyrrolo[2,3-d]pyrimidine

There total 4 articles about 4-N-(4-fluorophenyl)amino-5-phenyl-7-(2',3'-O-isopropylidene-4'-C-spirocyclopropyl-β-D-erythro-furanosyl)pyrrolo[2,3-d]pyrimidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: C₉H₁₃ClO₃

: 186393-47-5
4-N-(4-fluorophenyl)amino-5-phenylpyrrolo[2,3-d]pyrimidine

: 186456-76-8
4-N-(4-fluorophenyl)amino-5-phenyl-7-(2',3'-O-isopropylidene-4'-C-spirocyclopropyl-β-D-erythro-furanosyl)pyrrolo[2,3-d]pyrimidine

Guidance literature:: With potassium hydroxide; tris[2-(3-methoxyethoxy)ethyl]amine; In toluene; at 20 ℃; for 2h;
DOI:10.1021/jm0503650

Reference yield:

: (5R,6R,7S)-4-Oxa-spiro[2.4]heptane-5,6,7-triol

: 186456-76-8
4-N-(4-fluorophenyl)amino-5-phenyl-7-(2',3'-O-isopropylidene-4'-C-spirocyclopropyl-β-D-erythro-furanosyl)pyrrolo[2,3-d]pyrimidine

Guidance literature:: Multi-step reaction with 3 steps

1: 1.2 g / p-TsOH*H₂O / dimethylformamide / 4 h / 20 °C

2: hexamethylphosphorus triamide; CCl₄ / toluene / 1.5 h / -78 - 0 °C

3: 294 mg / KOH; tris[2-(3-methoxyethoxy)ethyl]amine / toluene / 2 h / 20 °C

With tetrachloromethane; N,N,N,N,N,N-hexamethylphosphoric triamide; potassium hydroxide; tris[2-(3-methoxyethoxy)ethyl]amine; toluene-4-sulfonic acid; In N,N-dimethyl-formamide; toluene;
DOI:10.1021/jm0503650

Reference yield:

: 186456-75-7
2,3-O-isopropylidene-4-C-spirocyclopropyl-D-erythro-pentofuranose

: 186456-76-8
4-N-(4-fluorophenyl)amino-5-phenyl-7-(2',3'-O-isopropylidene-4'-C-spirocyclopropyl-β-D-erythro-furanosyl)pyrrolo[2,3-d]pyrimidine

Guidance literature:: Multi-step reaction with 2 steps

1: hexamethylphosphorus triamide; CCl₄ / toluene / 1.5 h / -78 - 0 °C

2: 294 mg / KOH; tris[2-(3-methoxyethoxy)ethyl]amine / toluene / 2 h / 20 °C

With tetrachloromethane; N,N,N,N,N,N-hexamethylphosphoric triamide; potassium hydroxide; tris[2-(3-methoxyethoxy)ethyl]amine; In toluene;
DOI:10.1021/jm0503650