N⁶-(4-monomethoxytrityl)-9-<2,5-bis-O-(4-monomethoxytrityl)-β-D-arabinofuranosyl>adenine

Base Information

• Chemical Name: N⁶-(4-monomethoxytrityl)-9-<2,5-bis-O-(4-monomethoxytrityl)-β-D-arabinofuranosyl>adenine
• CAS No.: 115561-33-6
• Molecular Formula: C₇₀H₆₁N₅O₇
• Molecular Weight: 1084.28

Synonyms:N⁶-(4-monomethoxytrityl)-9-<2,5-bis-O-(4-monomethoxytrityl)-β-D-arabinofuranosyl>adenine

Chemical Property of N⁶-(4-monomethoxytrityl)-9-<2,5-bis-O-(4-monomethoxytrityl)-β-D-arabinofuranosyl>adenine

Chemical Property:

Purity/Quality:

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Technology Process of N⁶-(4-monomethoxytrityl)-9-<2,5-bis-O-(4-monomethoxytrityl)-β-D-arabinofuranosyl>adenine

There total 4 articles about N⁶-(4-monomethoxytrityl)-9-<2,5-bis-O-(4-monomethoxytrityl)-β-D-arabinofuranosyl>adenine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 78.0%

N6-(4-monomethoxytrityl)-9-<2-O-(4-monomethoxytrityl)-β-D-arabinofuranosyl>adenine (115561-32-5) + mono-4-methoxytrityl chloride (14470-28-1) → N6-(4-monomethoxytrityl)-9-<2,5-bis-O-(4-monomethoxytrityl)-β-D-arabinofuranosyl>adenine (115561-33-6)

Guidance literature:

In pyridine; for 10h; Ambient temperature;

DOI:10.1021/jm00118a006

Reference yield:

9-[3',5'-O-(1,1,3,3-tetraisopropyldisiloxane-1,3-diyl)-1-β-D-arabinofuranosyl]adenine (87792-02-7) → N6-(4-monomethoxytrityl)-9-<2,5-bis-O-(4-monomethoxytrityl)-β-D-arabinofuranosyl>adenine (115561-33-6)

Guidance literature:

Multi-step reaction with 3 steps

1: pyridine / 72 h / 65 °C

2: 72 percent / KF, Et₄NBr / acetonitrile / 1 h / 50 °C

3: 78 percent / pyridine / 10 h / Ambient temperature

With potassium fluoride; tetraethylammonium bromide; In pyridine; acetonitrile;

DOI:10.1021/jm00118a006

Reference yield:

[(4-Methoxy-phenyl)-diphenyl-methyl]-(9-{(2R,3S,3aR,9aR)-5,5,7,7-tetraisopropyl-3-[(4-methoxy-phenyl)-diphenyl-methoxy]-tetrahydro-1,4,6,8-tetraoxa-5,7-disila-cyclopentacycloocten-2-yl}-9H-purin-6-yl)-amine (115561-31-4) → N6-(4-monomethoxytrityl)-9-<2,5-bis-O-(4-monomethoxytrityl)-β-D-arabinofuranosyl>adenine (115561-33-6)

Guidance literature:

Multi-step reaction with 2 steps

1: 72 percent / KF, Et₄NBr / acetonitrile / 1 h / 50 °C

2: 78 percent / pyridine / 10 h / Ambient temperature

With potassium fluoride; tetraethylammonium bromide; In pyridine; acetonitrile;

DOI:10.1021/jm00118a006

upstream raw materials:

N⁶-(4-monomethoxytrityl)-9-<2-O-(4-monomethoxytrityl)-β-D-arabinofuranosyl>adenine

mono-4-methoxytrityl chloride

9-[3',5'-O-(1,1,3,3-tetraisopropyldisiloxane-1,3-diyl)-1-β-D-arabinofuranosyl]adenine

[(4-Methoxy-phenyl)-diphenyl-methyl]-(9-{(2R,3S,3aR,9aR)-5,5,7,7-tetraisopropyl-3-[(4-methoxy-phenyl)-diphenyl-methoxy]-tetrahydro-1,4,6,8-tetraoxa-5,7-disila-cyclopentacycloocten-2-yl}-9H-purin-6-yl)-amine

Downstream raw materials:

C₇₁H₆₃N₅O₉P^(1-)

C₇₀H₆₂N₅O₉P*C₆H₁₅N

C₁₄₀H₁₂₁N₁₀O₁₅P

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