Technology Process of (3S)-3-methyl-4-oxo-3,4-diphenylbutanal
There total 14 articles about (3S)-3-methyl-4-oxo-3,4-diphenylbutanal which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
(S)-2-methyl-1,2-diphenylpent-4-en-1-one;
With
ozone; triphenylphosphine;
In
dichloromethane;
at -78 - 20 ℃;
for 16h;
Inert atmosphere;
Inert atmosphere;
DOI:10.1021/jacs.5b02810
- Guidance literature:
-
With
oxalyl dichloride; dimethyl sulfoxide; triethylamine;
In
dichloromethane;
at -60 ℃;
for 2.33333h;
DOI:10.1021/ol025971t
- Guidance literature:
-
Multi-step reaction with 6 steps
1: 93 percent / N-chlorosuccinimide; dimethyl sulfide / CH2Cl2 / -40 - 0 °C
2: 84 percent / trichlorosilane; diisopropylethylamine; CuCl / diethyl ether / 18 h / 20 °C
3: tetrabutylammonium iodide / chiral bis(phosphoramide) / CH2Cl2 / 16 h / -78 °C
4: tetrahydrofuran / 3 h / Heating
5: 740 mg / sodium perborate; sodium hydroxide; 9-borabicyclo[3.3.1]nonane / tetrahydrofuran; H2O / 4 h / 50 °C
6: 87 percent / oxalyl chloride; DMSO; triethylamine / CH2Cl2 / 2.33 h / -60 °C
With
sodium hydroxide; N-chloro-succinimide; oxalyl dichloride; sodium perborate; dimethylsulfide; trichlorosilane; tetra-(n-butyl)ammonium iodide; dimethyl sulfoxide; triethylamine; N-ethyl-N,N-diisopropylamine; 9-bora-bicyclo[3.3.1]nonane; copper(l) chloride;
chiral bis(phosphoramide);
In
tetrahydrofuran; diethyl ether; dichloromethane; water;
6: Swern oxidation;
DOI:10.1021/ol025971t
