3-[3-(4-chloro-phenyl)-1-phenyl-1H-pyrazol-4-yl]-propionyl chloride

Base Information

• Chemical Name: 3-[3-(4-chloro-phenyl)-1-phenyl-1H-pyrazol-4-yl]-propionyl chloride
• CAS No.: 519137-54-3
• Molecular Formula: C₁₈H₁₄Cl₂N₂O
• Molecular Weight: 345.228
• Mol file: 519137-54-3.mol

Synonyms:3-[3-(4-chloro-phenyl)-1-phenyl-1H-pyrazol-4-yl]-propionyl chloride

Chemical Property of 3-[3-(4-chloro-phenyl)-1-phenyl-1H-pyrazol-4-yl]-propionyl chloride

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 3-[3-(4-chloro-phenyl)-1-phenyl-1H-pyrazol-4-yl]-propionyl chloride

There total 3 articles about 3-[3-(4-chloro-phenyl)-1-phenyl-1H-pyrazol-4-yl]-propionyl chloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 78.0%

β-[3-(p-Chlorophenyl)-1-phenylpyrazol-4-yl]propionic acid (108446-79-3) → 3-[3-(4-chloro-phenyl)-1-phenyl-1H-pyrazol-4-yl]-propionyl chloride (519137-54-3)

Guidance literature:

With thionyl chloride; In benzene; for 1h; Heating;

DOI:10.1023/A:1020905727368

Reference yield:

3-(3-(4-chlorophenyl)-1-phenyl-1H-pyrazol-4-yl)acrylic acid (55432-14-9,519137-40-7) → 3-[3-(4-chloro-phenyl)-1-phenyl-1H-pyrazol-4-yl]-propionyl chloride (519137-54-3)

Guidance literature:

Multi-step reaction with 2 steps

1: 58 percent / NaOH; hydrazine hydrate / Renay nickel / ethanol / Heating

2: 78 percent / thionyl chloride / benzene / 1 h / Heating

With sodium hydroxide; thionyl chloride; hydrazine hydrate; Renay nickel; In ethanol; benzene;

DOI:10.1023/A:1020905727368

Reference yield:

1-phenyl-3-(4-chlorophenyl)-4-pyrazolecarboxaldehyde (36663-00-0) → 3-[3-(4-chloro-phenyl)-1-phenyl-1H-pyrazol-4-yl]-propionyl chloride (519137-54-3)

Guidance literature:

Multi-step reaction with 3 steps

1: 83 percent / pyridine; piperidine / 4 h / Heating

2: 58 percent / NaOH; hydrazine hydrate / Renay nickel / ethanol / Heating

3: 78 percent / thionyl chloride / benzene / 1 h / Heating

With piperidine; pyridine; sodium hydroxide; thionyl chloride; hydrazine hydrate; Renay nickel; In ethanol; benzene;

DOI:10.1023/A:1020905727368

upstream raw materials:

β-[3-(p-Chlorophenyl)-1-phenylpyrazol-4-yl]propionic acid

3-(3-(4-chlorophenyl)-1-phenyl-1H-pyrazol-4-yl)acrylic acid

1-phenyl-3-(4-chlorophenyl)-4-pyrazolecarboxaldehyde