Ataprost

Base Information

Chemical Name:Ataprost
CAS No.:83997-19-7
Molecular Formula:C₂₁H₃₂O₄
Molecular Weight:348.483
Hs Code.:
UNII:M41LMG25QB
Nikkaji Number:J404.331F,J22.951B
Wikidata:Q27283461
NCI Thesaurus Code:C76895
ChEMBL ID:CHEMBL2104074

Synonyms:15-cyclopentyl-omega-pentanor-5(E)-carbacyclin;ataprost;ataprost, 3aS-(3aalpha,4alpha(1E,3R*),5beta,6aalpha)-isomer;ONO 41483;ONO-41483;OP 41483

Suppliers and Price of Ataprost

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
Ataprost
5mg
$ 1385.00

TRC
Ataprost
2.5mg
$ 725.00

American Custom Chemicals Corporation
ATAPROST 95.00%
5MG
$ 500.13

Total 0 raw suppliers

Chemical Property of Ataprost

Chemical Property:

Vapor Pressure:1.96E-13mmHg at 25°C
Boiling Point:529.8°C at 760 mmHg
Flash Point:288.3°C
PSA：77.76000
Density:1.255g/cm³
LogP:3.68200
XLogP3:2.7
Hydrogen Bond Donor Count:3
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:7
Exact Mass:348.23005950
Heavy Atom Count:25
Complexity:518

Purity/Quality:: Ataprost ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:C1CCC(C1)C(C=CC2C(CC3C2CC(=CCCCC(=O)O)C3)O)O
Isomeric SMILES:C1CCC(C1)[C@@H](/C=C/[C@H]2[C@@H](C[C@H]3[C@@H]2C/C(=C/CCCC(=O)O)/C3)O)O

Technology Process of Ataprost

There total 10 articles about Ataprost which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 74.0%

: 93380-22-4
Methyl (1S,5S,6R,7R)-6-<3(R)-Cyclopentyl-3-hydroxy-E-1-propenyl>-7-hydroxybicyclo<3.3.0>octane-E-Δ^3,δ-pentanoate

: 83997-19-7
(1S,5S,6R,7R)-6-<3(R)-Cyclopentyl-3-hydroxy-E-1-propenyl>-7-hydroxybicyclo<3.3.0>octan-E-Δ^3,δ-pentanoic Acid

Guidance literature:: With sodium hydroxide; In methanol; at 0 ℃;
DOI:10.1248/cpb.39.309

Reference yield:

: 58612-18-3
dimethyl (2-oxo-2-cyclopentylethyl)phosphonate

: 83997-19-7
(1S,5S,6R,7R)-6-<3(R)-Cyclopentyl-3-hydroxy-E-1-propenyl>-7-hydroxybicyclo<3.3.0>octan-E-Δ^3,δ-pentanoic Acid

Guidance literature:: Multi-step reaction with 7 steps

1: 1) NaH / 1) THF

2: NaBH₄ / methanol / -25 °C

3: 65percent aq. acetic acid / tetrahydrofuran / 50 °C

4: 94 percent / imidazole / dimethylformamide / 23 °C

5: 100 percent / H₂ / (methyl benzoate)*Cr(CO)3 / acetone / 15 h / 120 °C / 51485.6 Torr

6: 82 percent / tetrabutylammonium fluoride (TBAF) / tetrahydrofuran / 23 °C

7: 74 percent / 10percent aq. NaOH / methanol / 0 °C

With 1H-imidazole; sodium hydroxide; sodium tetrahydroborate; tetrabutyl ammonium fluoride; hydrogen; sodium hydride; acetic acid; (methyl benzoate)chromium tricarbonyl; In tetrahydrofuran; methanol; N,N-dimethyl-formamide; acetone;
DOI:10.1248/cpb.39.309

Reference yield:

: 101314-12-9
(E)-5-[(3aS,5R,6R,6aS)-6-Formyl-5-(tetrahydro-pyran-2-yloxy)-1,3a,4,5,6,6a-hexahydro-pentalen-2-yl]-pent-4-enoic acid methyl ester

: 83997-19-7
(1S,5S,6R,7R)-6-<3(R)-Cyclopentyl-3-hydroxy-E-1-propenyl>-7-hydroxybicyclo<3.3.0>octan-E-Δ^3,δ-pentanoic Acid

Guidance literature:: Multi-step reaction with 7 steps

1: 1) NaH / 1) THF

2: NaBH₄ / methanol / -25 °C

3: 65percent aq. acetic acid / tetrahydrofuran / 50 °C

4: 94 percent / imidazole / dimethylformamide / 23 °C

5: 100 percent / H₂ / (methyl benzoate)*Cr(CO)3 / acetone / 15 h / 120 °C / 51485.6 Torr

6: 82 percent / tetrabutylammonium fluoride (TBAF) / tetrahydrofuran / 23 °C

7: 74 percent / 10percent aq. NaOH / methanol / 0 °C

With 1H-imidazole; sodium hydroxide; sodium tetrahydroborate; tetrabutyl ammonium fluoride; hydrogen; sodium hydride; acetic acid; (methyl benzoate)chromium tricarbonyl; In tetrahydrofuran; methanol; N,N-dimethyl-formamide; acetone;
DOI:10.1248/cpb.39.309