((S)-1-Benzylcarbamoyl-propyl)-carbamic acid tert-butyl ester

Base Information

• Chemical Name: ((S)-1-Benzylcarbamoyl-propyl)-carbamic acid tert-butyl ester
• CAS No.: 1026257-87-3
• Molecular Formula: C₁₆H₂₄N₂O₃
• Molecular Weight: 292.378
• Mol file: 1026257-87-3.mol

Synonyms:((S)-1-Benzylcarbamoyl-propyl)-carbamic acid tert-butyl ester

Chemical Property of ((S)-1-Benzylcarbamoyl-propyl)-carbamic acid tert-butyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
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MSDS Files:

Useful:

Technology Process of ((S)-1-Benzylcarbamoyl-propyl)-carbamic acid tert-butyl ester

There total 1 articles about ((S)-1-Benzylcarbamoyl-propyl)-carbamic acid tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 77.0%

Boc-Abu (34306-42-8) + benzylamine (100-46-9) → ((S)-1-Benzylcarbamoyl-propyl)-carbamic acid tert-butyl ester (1026257-87-3)

Guidance literature:

With bis(cyclopentadienyl)hafnium dichloride; In diethyl ether; at 26 ℃; for 48h; Molecular sieve;

DOI:10.1021/acscatal.5b00385

Reference yield:

((S)-1-Benzylcarbamoyl-propyl)-carbamic acid tert-butyl ester (1026257-87-3) → (S)-2-Amino-N-benzyl-butyramide; hydrochloride

Guidance literature:

With hydrogenchloride; In ethyl acetate;

DOI:10.1021/jm00020a010

Reference yield:

((S)-1-Benzylcarbamoyl-propyl)-carbamic acid tert-butyl ester (1026257-87-3) → (S)-2-((R)-2-Amino-3-mercapto-propylamino)-N-benzyl-butyramide

Guidance literature:

Multi-step reaction with 3 steps

1: HCl gas / ethyl acetate

2: NaCNBH₃ / methanol

3: triethylsilane, TFA / CH₂Cl₂ / 1 h

With hydrogenchloride; triethylsilane; sodium cyanoborohydride; trifluoroacetic acid; In methanol; dichloromethane; ethyl acetate;

DOI:10.1021/jm00020a010

upstream raw materials:

Boc-Abu

benzylamine

Downstream raw materials:

{(R)-1-[((S)-1-Benzylcarbamoyl-propylamino)-methyl]-2-tritylsulfanyl-ethyl}-carbamic acid tert-butyl ester