(E)-ethyl 3-((S)-2-((R)-3-(4-methoxybenzyloxy)-1-(methoxymethoxy)propyl)oxiran-2-yl)acrylate

Base Information

• Chemical Name: (E)-ethyl 3-((S)-2-((R)-3-(4-methoxybenzyloxy)-1-(methoxymethoxy)propyl)oxiran-2-yl)acrylate
• CAS No.: 1197190-08-1
• Molecular Formula: C₂₀H₂₈O₇
• Molecular Weight: 380.438
• Mol file: 1197190-08-1.mol

Synonyms:(E)-ethyl 3-((S)-2-((R)-3-(4-methoxybenzyloxy)-1-(methoxymethoxy)propyl)oxiran-2-yl)acrylate

Chemical Property of (E)-ethyl 3-((S)-2-((R)-3-(4-methoxybenzyloxy)-1-(methoxymethoxy)propyl)oxiran-2-yl)acrylate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (E)-ethyl 3-((S)-2-((R)-3-(4-methoxybenzyloxy)-1-(methoxymethoxy)propyl)oxiran-2-yl)acrylate

There total 1 articles about (E)-ethyl 3-((S)-2-((R)-3-(4-methoxybenzyloxy)-1-(methoxymethoxy)propyl)oxiran-2-yl)acrylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

(E)-ethyl 3-((S)-2-((R)-3-(4-methoxybenzyloxy)-1-hydroxypropyl)oxiran-2-yl)acrylate (1197190-06-9) + chloromethyl methyl ether (107-30-2) → (E)-ethyl 3-((S)-2-((R)-3-(4-methoxybenzyloxy)-1-(methoxymethoxy)propyl)oxiran-2-yl)acrylate (1197190-08-1)

Guidance literature:

With N-ethyl-N,N-diisopropylamine; In dichloromethane; at 0 ℃; Reflux;

DOI:10.1039/b912267b

Reference yield: 98.0%

(E)-ethyl 3-((S)-2-((R)-3-(4-methoxybenzyloxy)-1-(methoxymethoxy)propyl)oxiran-2-yl)acrylate (1197190-08-1) → (E,4R,5R)-7-(4-methoxybenzyloxy)-5-(methoxymethoxy)-4-methylhept-2-ene-1,4-diol (1197190-10-5)

Guidance literature:

With lithium triethylborohydride; In tetrahydrofuran; at -78 - 0 ℃; for 1.25h;

DOI:10.1039/b912267b

Reference yield: 85.0%

(E)-ethyl 3-((S)-2-((R)-3-(4-methoxybenzyloxy)-1-(methoxymethoxy)propyl)oxiran-2-yl)acrylate (1197190-08-1) + rochelle salt (147-79-5,304-59-6,15490-42-3) → (E)-3-((S)-2-((R)-3-(4-methoxybenzyloxy)-1-(methoxymethoxy)propyl)oxiran-2-yl)prop-2-en-1-ol (1197190-18-3)

Guidance literature:

(E)-ethyl 3-((S)-2-((R)-3-(4-methoxybenzyloxy)-1-(methoxymethoxy)propyl)oxiran-2-yl)acrylate; With diisobutylaluminium hydride; In tetrahydrofuran; hexane; at -78 ℃; for 1h;

rochelle salt; In tetrahydrofuran; hexane; ethyl acetate; at -78 - 20 ℃; for 1h; regioselective reaction;

DOI:10.1039/b912267b

upstream raw materials:

(E)-ethyl 3-((S)-2-((R)-3-(4-methoxybenzyloxy)-1-hydroxypropyl)oxiran-2-yl)acrylate

chloromethyl methyl ether

Downstream raw materials:

(E,4R,5R)-7-(4-methoxybenzyloxy)-5-(methoxymethoxy)-4-methylhept-2-ene-1,4-diol

(E)-3-((S)-2-((R)-3-(4-methoxybenzyloxy)-1-(methoxymethoxy)propyl)oxiran-2-yl)prop-2-en-1-ol