(1S,2R)-1-(4-nitrophenyl)-2-nitropropan-1-ol

Base Information

• Chemical Name: (1S,2R)-1-(4-nitrophenyl)-2-nitropropan-1-ol
• CAS No.: 1040923-95-2
• Molecular Formula: C₉H₁₀N₂O₅
• Molecular Weight: 226.189
• Mol file: 1040923-95-2.mol

Synonyms:(1S,2R)-1-(4-nitrophenyl)-2-nitropropan-1-ol

Chemical Property of (1S,2R)-1-(4-nitrophenyl)-2-nitropropan-1-ol

Chemical Property:

Purity/Quality:

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MSDS Files:

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Technology Process of (1S,2R)-1-(4-nitrophenyl)-2-nitropropan-1-ol

There total 10 articles about (1S,2R)-1-(4-nitrophenyl)-2-nitropropan-1-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

Nitroethane (79-24-3) + 4-nitrobenzaldehdye (555-16-8) → (1S,2R)-1-(4-nitrophenyl)-2-nitropropan-1-ol (1040923-95-2) + C9H10N2O5 (14438-62-1)

Guidance literature:

With C₁₁H₂₀Cl₂CuN₂O; triethylamine; In methanol; at -10 ℃; for 68h; optical yield given as %ee; enantioselective reaction;

DOI:10.1002/chem.200901789

Reference yield: 90.0%

Nitroethane (79-24-3) + 4-nitrobenzaldehdye (555-16-8) → (1S,2R)-1-(4-nitrophenyl)-2-nitropropan-1-ol (1040923-95-2)

Guidance literature:

Nitroethane; With (S)-2-((2-(hydroxydiphenylmethyl)pyrrolidin-1-yl)methyl)-6-(trifluoromethyl)phenol; caesium carbonate; copper(ll) bromide; In tetrahydrofuran; at 20 ℃; for 4h;

4-nitrobenzaldehdye; In tetrahydrofuran; at -15 ℃; for 72h; diastereoselective reaction;

DOI:10.1002/chem.201201775

Reference yield:

Nitroethane (79-24-3) + 4-nitrobenzaldehdye (555-16-8) → (1R,2R)-1-(4-nitrophenyl)-2-nitropropan-1-ol + (1S,2S)-2-nitro-1-(4-nitrophenyl)propan-1-ol (929260-31-1) + (1S,2R)-1-(4-nitrophenyl)-2-nitropropan-1-ol (1040923-95-2) + (1R,2S)-1-(4-nitrophenyl)-2-nitropropan-1-ol (1190603-31-6)

Guidance literature:

4-nitrobenzaldehdye; With copper(II) acetate monohydrate; (1R,2R)-N,N'-di(anthracenyl-9'-methylene)-1,2-diaminocyclohexane; In isopropyl alcohol; at -30 - 23 ℃; for 0.25h;

Nitroethane; With N-ethyl-N,N-diisopropylamine; In isopropyl alcohol; at -30 ℃; for 70h; optical yield given as %ee;

DOI:10.1016/j.tetasy.2009.10.001

upstream raw materials:

Nitroethane

4-nitrobenzaldehdye

nitromethane