hemiketal of 6(R)-<1(R)-methyl-2-<(tert-butyldiphenylsilyl)oxy>ethyl>-4(S)-<7-(tert-butoxycarbonyl)-1(R),5(R)-dimethyl-6(S)-hydroxy-2-oxoheptanyl>-2,2,5(S)-trimethyl-1,3-dioxane

Base Information

Chemical Name:hemiketal of 6(R)-<1(R)-methyl-2-<(tert-butyldiphenylsilyl)oxy>ethyl>-4(S)-<7-(tert-butoxycarbonyl)-1(R),5(R)-dimethyl-6(S)-hydroxy-2-oxoheptanyl>-2,2,5(S)-trimethyl-1,3-dioxane
CAS No.:122213-39-2
Molecular Formula:C₄₀H₆₂O₇Si
Molecular Weight:683.014
Hs Code.:

hemiketal of 6(R)-<1(R)-methyl-2-<(tert-butyldiphenylsilyl)oxy>ethyl>-4(S)-<7-(tert-butoxycarbonyl)-1(R),5(R)-dimethyl-6(S)-hydroxy-2-oxoheptanyl>-2,2,5(S)-trimethyl-1,3-dioxane

Synonyms:hemiketal of 6(R)-<1(R)-methyl-2-<(tert-butyldiphenylsilyl)oxy>ethyl>-4(S)-<7-(tert-butoxycarbonyl)-1(R),5(R)-dimethyl-6(S)-hydroxy-2-oxoheptanyl>-2,2,5(S)-trimethyl-1,3-dioxane

Suppliers and Price of hemiketal of 6(R)-<1(R)-methyl-2-<(tert-butyldiphenylsilyl)oxy>ethyl>-4(S)-<7-(tert-butoxycarbonyl)-1(R),5(R)-dimethyl-6(S)-hydroxy-2-oxoheptanyl>-2,2,5(S)-trimethyl-1,3-dioxane

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of hemiketal of 6(R)-<1(R)-methyl-2-<(tert-butyldiphenylsilyl)oxy>ethyl>-4(S)-<7-(tert-butoxycarbonyl)-1(R),5(R)-dimethyl-6(S)-hydroxy-2-oxoheptanyl>-2,2,5(S)-trimethyl-1,3-dioxane

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of hemiketal of 6(R)-<1(R)-methyl-2-<(tert-butyldiphenylsilyl)oxy>ethyl>-4(S)-<7-(tert-butoxycarbonyl)-1(R),5(R)-dimethyl-6(S)-hydroxy-2-oxoheptanyl>-2,2,5(S)-trimethyl-1,3-dioxane

There total 13 articles about hemiketal of 6(R)-<1(R)-methyl-2-<(tert-butyldiphenylsilyl)oxy>ethyl>-4(S)-<7-(tert-butoxycarbonyl)-1(R),5(R)-dimethyl-6(S)-hydroxy-2-oxoheptanyl>-2,2,5(S)-trimethyl-1,3-dioxane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 122213-31-4
(E)-(R)-3,6-Dimethyl-hept-4-en-1-ol

: 122213-39-2
hemiketal of 6(R)-<1(R)-methyl-2-<(tert-butyldiphenylsilyl)oxy>ethyl>-4(S)-<7-(tert-butoxycarbonyl)-1(R),5(R)-dimethyl-6(S)-hydroxy-2-oxoheptanyl>-2,2,5(S)-trimethyl-1,3-dioxane

Guidance literature:: Multi-step reaction with 7 steps

1: 1.) triethylamine, methanesulfonyl chloride, 2.) LiBr / 1.) CH₂Cl₂, 0 deg C, 30 min, 2.) acetone, reflux

2: 48 percent / dimethylformamide / Ambient temperature

3: 1.) n-BuLi / 1.) THF, -78 deg C, 45 min, 2.) a) THF, -78 deg C, 50 min, b) 0 deg C, 30 min

4: oxalyl chloride, DMSO / CH₂Cl₂ / 0.25 h / -78 °C

5: 74 mg / disodium hydrogen phosphate, Na/Hg / methanol / 2.5 h / 0 °C

6: 1.) O₃, NaHCO₃, 2.) dimethyl sulfide / 1.) MeOH, CH₂Cl₂, -78 deg C, 2.) a) -78 deg C, 10 min, b) RT, 1.5 h

7: 1.) lithium diisopropylamide / 1.) THF, -78 deg C, 30 min, 2.) -78 deg C, 5 min

With disodium hydrogenphosphate; sodium amalgam; n-butyllithium; oxalyl dichloride; dimethylsulfide; sodium hydrogencarbonate; ozone; dimethyl sulfoxide; methanesulfonyl chloride; triethylamine; lithium bromide; lithium diisopropyl amide; In methanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/jo00275a019

Reference yield:

: 122213-32-5
(E)-(R)-7-Bromo-2,5-dimethyl-hept-3-ene

: 122213-39-2
hemiketal of 6(R)-<1(R)-methyl-2-<(tert-butyldiphenylsilyl)oxy>ethyl>-4(S)-<7-(tert-butoxycarbonyl)-1(R),5(R)-dimethyl-6(S)-hydroxy-2-oxoheptanyl>-2,2,5(S)-trimethyl-1,3-dioxane

Guidance literature:: Multi-step reaction with 6 steps

1: 48 percent / dimethylformamide / Ambient temperature

2: 1.) n-BuLi / 1.) THF, -78 deg C, 45 min, 2.) a) THF, -78 deg C, 50 min, b) 0 deg C, 30 min

3: oxalyl chloride, DMSO / CH₂Cl₂ / 0.25 h / -78 °C

4: 74 mg / disodium hydrogen phosphate, Na/Hg / methanol / 2.5 h / 0 °C

5: 1.) O₃, NaHCO₃, 2.) dimethyl sulfide / 1.) MeOH, CH₂Cl₂, -78 deg C, 2.) a) -78 deg C, 10 min, b) RT, 1.5 h

6: 1.) lithium diisopropylamide / 1.) THF, -78 deg C, 30 min, 2.) -78 deg C, 5 min

With disodium hydrogenphosphate; sodium amalgam; n-butyllithium; oxalyl dichloride; dimethylsulfide; sodium hydrogencarbonate; ozone; dimethyl sulfoxide; lithium diisopropyl amide; In methanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/jo00275a019

Reference yield:

: 122213-30-3
(E)-(R)-3,6-Dimethyl-hept-4-enoic acid methyl ester

: 122213-39-2
hemiketal of 6(R)-<1(R)-methyl-2-<(tert-butyldiphenylsilyl)oxy>ethyl>-4(S)-<7-(tert-butoxycarbonyl)-1(R),5(R)-dimethyl-6(S)-hydroxy-2-oxoheptanyl>-2,2,5(S)-trimethyl-1,3-dioxane

Guidance literature:: Multi-step reaction with 8 steps

1: LiAlH₄ / diethyl ether / Ambient temperature

2: 1.) triethylamine, methanesulfonyl chloride, 2.) LiBr / 1.) CH₂Cl₂, 0 deg C, 30 min, 2.) acetone, reflux

3: 48 percent / dimethylformamide / Ambient temperature

4: 1.) n-BuLi / 1.) THF, -78 deg C, 45 min, 2.) a) THF, -78 deg C, 50 min, b) 0 deg C, 30 min

5: oxalyl chloride, DMSO / CH₂Cl₂ / 0.25 h / -78 °C

6: 74 mg / disodium hydrogen phosphate, Na/Hg / methanol / 2.5 h / 0 °C

7: 1.) O₃, NaHCO₃, 2.) dimethyl sulfide / 1.) MeOH, CH₂Cl₂, -78 deg C, 2.) a) -78 deg C, 10 min, b) RT, 1.5 h

8: 1.) lithium diisopropylamide / 1.) THF, -78 deg C, 30 min, 2.) -78 deg C, 5 min

With disodium hydrogenphosphate; sodium amalgam; lithium aluminium tetrahydride; n-butyllithium; oxalyl dichloride; dimethylsulfide; sodium hydrogencarbonate; ozone; dimethyl sulfoxide; methanesulfonyl chloride; triethylamine; lithium bromide; lithium diisopropyl amide; In methanol; diethyl ether; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/jo00275a019