3-Hydroxy-4-[2-(3-trifluoromethyl-phenyl)-thiazol-4-yl]-pyrrole-2,5-dione

Base Information

• Chemical Name: 3-Hydroxy-4-[2-(3-trifluoromethyl-phenyl)-thiazol-4-yl]-pyrrole-2,5-dione
• CAS No.: 78764-60-0
• Molecular Formula: C₁₄H₇F₃N₂O₃S
• Molecular Weight: 340.282
• Mol file: 78764-60-0.mol

Synonyms:3-Hydroxy-4-[2-(3-trifluoromethyl-phenyl)-thiazol-4-yl]-pyrrole-2,5-dione

Chemical Property of 3-Hydroxy-4-[2-(3-trifluoromethyl-phenyl)-thiazol-4-yl]-pyrrole-2,5-dione

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 3-Hydroxy-4-[2-(3-trifluoromethyl-phenyl)-thiazol-4-yl]-pyrrole-2,5-dione

There total 3 articles about 3-Hydroxy-4-[2-(3-trifluoromethyl-phenyl)-thiazol-4-yl]-pyrrole-2,5-dione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 69.0%

oxalic acid diethyl ester (95-92-1) + 2-[2-(3-Trifluoromethyl-phenyl)-thiazol-4-yl]-acetamide (78743-06-3) → 3-Hydroxy-4-[2-(3-trifluoromethyl-phenyl)-thiazol-4-yl]-pyrrole-2,5-dione (78764-60-0)

Guidance literature:

With potassium tert-butylate; In N,N-dimethyl-formamide; Ambient temperature;

DOI:10.1021/jm00359a015

Reference yield:

3-(trifluoromethyl)benzothioamide (53515-17-6) → 3-Hydroxy-4-[2-(3-trifluoromethyl-phenyl)-thiazol-4-yl]-pyrrole-2,5-dione (78764-60-0)

Guidance literature:

Multi-step reaction with 3 steps

1: 57 percent / ethanol / 4 h / Heating

2: 70 percent / NH₄OH / dioxane / 120 h / Ambient temperature

3: 69 percent / t-BuOK / dimethylformamide / Ambient temperature

With ammonium hydroxide; potassium tert-butylate; In 1,4-dioxane; ethanol; N,N-dimethyl-formamide;

DOI:10.1021/jm00359a015

Reference yield:

[2-(3-Trifluoromethyl-phenyl)-thiazol-4-yl]-acetic acid ethyl ester (78743-00-7) → 3-Hydroxy-4-[2-(3-trifluoromethyl-phenyl)-thiazol-4-yl]-pyrrole-2,5-dione (78764-60-0)

Guidance literature:

Multi-step reaction with 2 steps

1: 70 percent / NH₄OH / dioxane / 120 h / Ambient temperature

2: 69 percent / t-BuOK / dimethylformamide / Ambient temperature

With ammonium hydroxide; potassium tert-butylate; In 1,4-dioxane; N,N-dimethyl-formamide;

DOI:10.1021/jm00359a015

upstream raw materials:

oxalic acid diethyl ester

2-[2-(3-Trifluoromethyl-phenyl)-thiazol-4-yl]-acetamide

3-(trifluoromethyl)benzothioamide

[2-(3-Trifluoromethyl-phenyl)-thiazol-4-yl]-acetic acid ethyl ester