4-(2-{4-[4-(4-iodo-phenylethynyl)-3-methyl-phenylethynyl]-phenylsulfanyl}-ethyl)-pyridine

Base Information

Chemical Name:4-(2-{4-[4-(4-iodo-phenylethynyl)-3-methyl-phenylethynyl]-phenylsulfanyl}-ethyl)-pyridine
CAS No.:221292-56-4
Molecular Formula:C₃₀H₂₂INS
Molecular Weight:555.482
Hs Code.:

Synonyms:4-(2-{4-[4-(4-iodo-phenylethynyl)-3-methyl-phenylethynyl]-phenylsulfanyl}-ethyl)-pyridine

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Chemical Property of 4-(2-{4-[4-(4-iodo-phenylethynyl)-3-methyl-phenylethynyl]-phenylsulfanyl}-ethyl)-pyridine

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Technology Process of 4-(2-{4-[4-(4-iodo-phenylethynyl)-3-methyl-phenylethynyl]-phenylsulfanyl}-ethyl)-pyridine

There total 16 articles about 4-(2-{4-[4-(4-iodo-phenylethynyl)-3-methyl-phenylethynyl]-phenylsulfanyl}-ethyl)-pyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 81.0%

: 624-38-4,1032416-46-8
para-diiodobenzene

: 207724-69-4
4-{2-[4-(4-ethynyl-3-methyl-phenylethynyl)-phenylsulfanyl]-ethyl}-pyridine

: 221292-56-4
4-(2-{4-[4-(4-iodo-phenylethynyl)-3-methyl-phenylethynyl]-phenylsulfanyl}-ethyl)-pyridine

Guidance literature:: With copper(l) iodide; diisopropylamine; triphenylphosphine; bis(dibenzylideneacetone)-palladium⁽⁰⁾; In tetrahydrofuran; at 60 ℃; for 16h;
DOI:10.1021/jo982392m

Reference yield:

: 100-43-6,329041-72-7
4-vinylpyridine

: 221292-56-4
4-(2-{4-[4-(4-iodo-phenylethynyl)-3-methyl-phenylethynyl]-phenylsulfanyl}-ethyl)-pyridine

Guidance literature:: Multi-step reaction with 6 steps

1: 46 percent / benzene / Heating

2: 81.4 percent / Pd(PPh₃)2Cl₂, CuI, Et₂NH / 2 h / 55 °C

3: 94.1 percent / Bu₄NF / tetrahydrofuran; CH₂Cl₂ / 1.5 h

4: 71 percent / Pd(dba)2, PPh₃, CuI, diisopropylamine / tetrahydrofuran / 4 h / 60 °C

5: 81.3 percent / Bu₄NF / tetrahydrofuran; CH₂Cl₂ / 0.5 h

6: 81 percent / Pd(dba)2, PPh₃, CuI, diisopropylamine / tetrahydrofuran / 16 h / 60 °C

With bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; tetrabutyl ammonium fluoride; diethylamine; diisopropylamine; triphenylphosphine; bis(dibenzylideneacetone)-palladium⁽⁰⁾; In tetrahydrofuran; dichloromethane; benzene;
DOI:10.1021/jo982392m

Reference yield:

: 62237-50-7
2-(4-pyridinyl)ethyl-4'-bromophenyl sulfide

: 221292-56-4
4-(2-{4-[4-(4-iodo-phenylethynyl)-3-methyl-phenylethynyl]-phenylsulfanyl}-ethyl)-pyridine

Guidance literature:: Multi-step reaction with 5 steps

1: 94 percent / Pd(dba)2, PPh₃, CuI, diisopropylamine / dimethylformamide / 60 °C

2: 94.1 percent / Bu₄NF / tetrahydrofuran; CH₂Cl₂ / 1.5 h

3: 71 percent / Pd(dba)2, PPh₃, CuI, diisopropylamine / tetrahydrofuran / 4 h / 60 °C

4: 81.3 percent / Bu₄NF / tetrahydrofuran; CH₂Cl₂ / 0.5 h

5: 81 percent / Pd(dba)2, PPh₃, CuI, diisopropylamine / tetrahydrofuran / 16 h / 60 °C

With copper(l) iodide; tetrabutyl ammonium fluoride; diisopropylamine; triphenylphosphine; bis(dibenzylideneacetone)-palladium⁽⁰⁾; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/jo982392m