(3S)-2,3-dihydro-3-methyl-1H-indole-1-carboxylic acid 1,1-dimethylethyl ester

Base Information

• Chemical Name: (3S)-2,3-dihydro-3-methyl-1H-indole-1-carboxylic acid 1,1-dimethylethyl ester
• CAS No.: 899419-87-5
• Molecular Formula: C₁₄H₁₉NO₂
• Molecular Weight: 233.31

Synonyms:(3S)-2,3-dihydro-3-methyl-1H-indole-1-carboxylic acid 1,1-dimethylethyl ester

Chemical Property of (3S)-2,3-dihydro-3-methyl-1H-indole-1-carboxylic acid 1,1-dimethylethyl ester

Chemical Property:

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Technology Process of (3S)-2,3-dihydro-3-methyl-1H-indole-1-carboxylic acid 1,1-dimethylethyl ester

There total 1 articles about (3S)-2,3-dihydro-3-methyl-1H-indole-1-carboxylic acid 1,1-dimethylethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

3-Methylindole (83-34-1) → (3S)-2,3-dihydro-3-methyl-1H-indole-1-carboxylic acid 1,1-dimethylethyl ester (899419-87-5)

Guidance literature:

Multi-step reaction with 2 steps

1: 100 percent / 4-(dimethylamino)pyridine / acetonitrile / 22 h / 20 °C

2: cesium carbonate; hydrogen / bisferrocene-based chiral biphosphine ruthenium complex / 24 h / 40 °C / 38000 Torr

With dmap; hydrogen; caesium carbonate; bisferrocene-based chiral biphosphine ruthenium; In acetonitrile;

DOI:10.1021/ol061039x

Reference yield:

(3S)-2,3-dihydro-3-methyl-1H-indole-1-carboxylic acid 1,1-dimethylethyl ester (899419-87-5) → (3S)-1-benzyl-3-methyl-2,3-dihydro-1H-indol

Guidance literature:

Multi-step reaction with 2 steps

1: HCl / ethyl acetate; H₂O / 4 h / 0 - 20 °C

2: K₂CO₃; KI / dimethylformamide / 1 h / 100 °C

With hydrogenchloride; potassium carbonate; potassium iodide; In water; ethyl acetate; N,N-dimethyl-formamide;

DOI:10.1021/ol061039x

upstream raw materials:

3-Methylindole

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