(S)-(-)-2-<3-<4-(4-fluorophenyl)-1-piperazinyl>propyl>-6,7,8,9-tetrahydro-2H-naphtho<2,3-b><1,4>oxazin-3(4H)-one

Base Information

Chemical Name:(S)-(-)-2-<3-<4-(4-fluorophenyl)-1-piperazinyl>propyl>-6,7,8,9-tetrahydro-2H-naphtho<2,3-b><1,4>oxazin-3(4H)-one
CAS No.:112249-69-1
Molecular Formula:C₂₅H₃₀FN₃O₂
Molecular Weight:423.531
Hs Code.:

Synonyms:(S)-(-)-2-<3-<4-(4-fluorophenyl)-1-piperazinyl>propyl>-6,7,8,9-tetrahydro-2H-naphtho<2,3-b><1,4>oxazin-3(4H)-one

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Chemical Property of (S)-(-)-2-<3-<4-(4-fluorophenyl)-1-piperazinyl>propyl>-6,7,8,9-tetrahydro-2H-naphtho<2,3-b><1,4>oxazin-3(4H)-one

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Technology Process of (S)-(-)-2-<3-<4-(4-fluorophenyl)-1-piperazinyl>propyl>-6,7,8,9-tetrahydro-2H-naphtho<2,3-b><1,4>oxazin-3(4H)-one

There total 13 articles about (S)-(-)-2-<3-<4-(4-fluorophenyl)-1-piperazinyl>propyl>-6,7,8,9-tetrahydro-2H-naphtho<2,3-b><1,4>oxazin-3(4H)-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 59.6%

: 1-(4-fluorophenylpiperazine

: ethyl acetate n-hexane

: 112249-74-8
(S)-(+)-6,7,8,9-tetrahydro-2-(3-methanesulfonyloxypropyl)-2H-naphtho<2,3-b><1,4>oxazin-3(4H)-one

: 112249-69-1
(S)-(-)-2-<3-<4-(4-fluorophenyl)-1-piperazinyl>propyl>-6,7,8,9-tetrahydro-2H-naphtho<2,3-b><1,4>oxazin-3(4H)-one

Guidance literature:: With triethylamine; In N-methyl-acetamide;

Reference yield: 59.6%

: 112249-74-8
(S)-(+)-6,7,8,9-tetrahydro-2-(3-methanesulfonyloxypropyl)-2H-naphtho<2,3-b><1,4>oxazin-3(4H)-one

: 2252-63-3
1-(4-Fluorophenyl)piperazine

: 112249-69-1
(S)-(-)-2-<3-<4-(4-fluorophenyl)-1-piperazinyl>propyl>-6,7,8,9-tetrahydro-2H-naphtho<2,3-b><1,4>oxazin-3(4H)-one

Guidance literature:: With triethylamine; In N,N-dimethyl-formamide; at 70 ℃; for 2.5h;
DOI:10.1248/cpb.39.2896

Reference yield:

: 1125-78-6
5,6,7,8-Tetrahydro-2-naphthol

: 112249-69-1
(S)-(-)-2-<3-<4-(4-fluorophenyl)-1-piperazinyl>propyl>-6,7,8,9-tetrahydro-2H-naphtho<2,3-b><1,4>oxazin-3(4H)-one

Guidance literature:: Multi-step reaction with 7 steps

1: 24.6 percent / NaNO₃, La(NO₃)3*6H₂O, 6 N HCl / diethyl ether / 20 h / Ambient temperature

2: 97 percent / 47percent HBr, H₂ / 10percent Pd/C / methanol

3: NaHCO₃ / ethyl acetate; H₂O / 1 h / 0 °C

4: K₂CO₃ / dimethylformamide / 1 h / Ambient temperature

5: 98.7 percent / LiAlH₄ / tetrahydrofuran / 1.5 h / 0 °C

6: 79.7 percent / NEt₃ / CH₂Cl₂ / 1.5 h / 0 °C

7: 59.6 percent / NEt₃ / dimethylformamide / 2.5 h / 70 °C

With hydrogenchloride; sodium nitrate; lithium aluminium tetrahydride; hydrogen bromide; hydrogen; sodium hydrogencarbonate; potassium carbonate; lanthanum(III) nitrate; triethylamine; palladium on activated charcoal; In tetrahydrofuran; methanol; diethyl ether; dichloromethane; water; ethyl acetate; N,N-dimethyl-formamide;
DOI:10.1248/cpb.39.2896