trans-1,4-Bis(difluoromethyl)-1,4-bis<<<(trifluoromethyl)sulfonyl>oxy>methyl>cyclohexane

Base Information

Chemical Name:trans-1,4-Bis(difluoromethyl)-1,4-bis<<<(trifluoromethyl)sulfonyl>oxy>methyl>cyclohexane
CAS No.:153032-57-6
Molecular Formula:C₁₂H₁₄F₁₀O₆S₂
Molecular Weight:508.356
Hs Code.:

Synonyms:trans-1,4-Bis(difluoromethyl)-1,4-bis<<<(trifluoromethyl)sulfonyl>oxy>methyl>cyclohexane

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Chemical Property of trans-1,4-Bis(difluoromethyl)-1,4-bis<<<(trifluoromethyl)sulfonyl>oxy>methyl>cyclohexane

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Technology Process of trans-1,4-Bis(difluoromethyl)-1,4-bis<<<(trifluoromethyl)sulfonyl>oxy>methyl>cyclohexane

There total 6 articles about trans-1,4-Bis(difluoromethyl)-1,4-bis<<<(trifluoromethyl)sulfonyl>oxy>methyl>cyclohexane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

: 358-23-6
trifluoromethylsulfonic anhydride

: 153032-56-5
trans-1,4-Bis(difluoromethyl)-1,4-cyclohexanedimethanol

: 153032-57-6
trans-1,4-Bis(difluoromethyl)-1,4-bis<<<(trifluoromethyl)sulfonyl>oxy>methyl>cyclohexane

Guidance literature:: With pyridine; In dichloromethane; for 2h; Ambient temperature;
DOI:10.1021/jo00076a055

Reference yield:

: 94-60-0
dimethyl 1,4-cyclohexane dicarboxylate

: 153032-57-6
trans-1,4-Bis(difluoromethyl)-1,4-bis<<<(trifluoromethyl)sulfonyl>oxy>methyl>cyclohexane

Guidance literature:: Multi-step reaction with 6 steps

1: 87 percent / diisopropylamine, n-BuLi / tetrahydrofuran; hexane / 1.) -78 deg C, 1 h, 2.) -68 deg C -> r.t.

2: 85 percent / 2,2,6,6-tetramethylpiperidine, n-BuLi / tetrahydrofuran; hexane / 1.) -78 deg C, 1 h, 2.) -70 deg C

3: 63 percent / DIBALH / CH₂Cl₂ / 3 h / -78 °C

4: (diethylamido)sulfur trifluoride / CH₂Cl₂ / 10 h / Ambient temperature

5: 91 percent / LiAlH₄ / diethyl ether / 8 h / Ambient temperature

6: 87 percent / pyridine / CH₂Cl₂ / 2 h / Ambient temperature

With pyridine; 2,2,6,6-tetramethyl-piperidine; lithium aluminium tetrahydride; n-butyllithium; (diethylamido)sulfur trifluoride; diisobutylaluminium hydride; diisopropylamine; In tetrahydrofuran; diethyl ether; hexane; dichloromethane;
DOI:10.1021/jo00076a055

Reference yield:

: 153032-50-9
Trimethyl 1,1,4-cyclohexanetricarboxylate

: 153032-57-6
trans-1,4-Bis(difluoromethyl)-1,4-bis<<<(trifluoromethyl)sulfonyl>oxy>methyl>cyclohexane

Guidance literature:: Multi-step reaction with 5 steps

1: 85 percent / 2,2,6,6-tetramethylpiperidine, n-BuLi / tetrahydrofuran; hexane / 1.) -78 deg C, 1 h, 2.) -70 deg C

2: 63 percent / DIBALH / CH₂Cl₂ / 3 h / -78 °C

3: (diethylamido)sulfur trifluoride / CH₂Cl₂ / 10 h / Ambient temperature

4: 91 percent / LiAlH₄ / diethyl ether / 8 h / Ambient temperature

5: 87 percent / pyridine / CH₂Cl₂ / 2 h / Ambient temperature

With pyridine; 2,2,6,6-tetramethyl-piperidine; lithium aluminium tetrahydride; n-butyllithium; (diethylamido)sulfur trifluoride; diisobutylaluminium hydride; In tetrahydrofuran; diethyl ether; hexane; dichloromethane;
DOI:10.1021/jo00076a055