methyl 5'-[4-({(4S,5R)-5-[3,5-bis(trifluoromethyl)phenyl]-4-methyl-2-oxo-1,3-oxazolidin-3-yl}methyl)-2-(methylsulfanyl)pyrimidin-5-yl]-2'-fluoro-2-methylbiphenyl-4-carboxylate

Base Information

Chemical Name:methyl 5'-[4-({(4S,5R)-5-[3,5-bis(trifluoromethyl)phenyl]-4-methyl-2-oxo-1,3-oxazolidin-3-yl}methyl)-2-(methylsulfanyl)pyrimidin-5-yl]-2'-fluoro-2-methylbiphenyl-4-carboxylate
CAS No.:1374135-36-0
Molecular Formula:C₃₃H₂₆F₇N₃O₄S
Molecular Weight:693.642
Hs Code.:

methyl 5'-[4-({(4S,5R)-5-[3,5-bis(trifluoromethyl)phenyl]-4-methyl-2-oxo-1,3-oxazolidin-3-yl}methyl)-2-(methylsulfanyl)pyrimidin-5-yl]-2'-fluoro-2-methylbiphenyl-4-carboxylate

Synonyms:methyl 5'-[4-({(4S,5R)-5-[3,5-bis(trifluoromethyl)phenyl]-4-methyl-2-oxo-1,3-oxazolidin-3-yl}methyl)-2-(methylsulfanyl)pyrimidin-5-yl]-2'-fluoro-2-methylbiphenyl-4-carboxylate

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Chemical Property of methyl 5'-[4-({(4S,5R)-5-[3,5-bis(trifluoromethyl)phenyl]-4-methyl-2-oxo-1,3-oxazolidin-3-yl}methyl)-2-(methylsulfanyl)pyrimidin-5-yl]-2'-fluoro-2-methylbiphenyl-4-carboxylate

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Technology Process of methyl 5'-[4-({(4S,5R)-5-[3,5-bis(trifluoromethyl)phenyl]-4-methyl-2-oxo-1,3-oxazolidin-3-yl}methyl)-2-(methylsulfanyl)pyrimidin-5-yl]-2'-fluoro-2-methylbiphenyl-4-carboxylate

There total 7 articles about methyl 5'-[4-({(4S,5R)-5-[3,5-bis(trifluoromethyl)phenyl]-4-methyl-2-oxo-1,3-oxazolidin-3-yl}methyl)-2-(methylsulfanyl)pyrimidin-5-yl]-2'-fluoro-2-methylbiphenyl-4-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1374135-33-7
(4S,5R)-5-[3,5-bis(trifluoromethyl)phenyl]-3-{[5-(4-fluoro-3-iodophenyl)-2-(methylsulfanyl)pyrimidin-4-yl]methyl}-4-methyl-1,3-oxazolidin-2-one

: 473596-87-1
4-methoxycarbonyl-2-methylbenzeneboronic acid pinacol ester

: 1374135-36-0
methyl 5'-[4-({(4S,5R)-5-[3,5-bis(trifluoromethyl)phenyl]-4-methyl-2-oxo-1,3-oxazolidin-3-yl}methyl)-2-(methylsulfanyl)pyrimidin-5-yl]-2'-fluoro-2-methylbiphenyl-4-carboxylate

Guidance literature:: With sodium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In ethanol; water; toluene; at 80 ℃; for 1h;

Reference yield:

: 1233083-43-6
(4S,5R)-5-[3,5-bis(trifluoromethyl)phenyl]-3-{[5-bromo-2-(methylsulfanyl)pyrimidin-4-yl]methyl}-4-methyl-1,3-oxazolidin-2-one

: 1374135-36-0
methyl 5'-[4-({(4S,5R)-5-[3,5-bis(trifluoromethyl)phenyl]-4-methyl-2-oxo-1,3-oxazolidin-3-yl}methyl)-2-(methylsulfanyl)pyrimidin-5-yl]-2'-fluoro-2-methylbiphenyl-4-carboxylate

Guidance literature:: Multi-step reaction with 3 steps

1: sodium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / ethanol; water; toluene / 1 h / 80 °C

2: n-Amyl nitrite; iodine / chloroform / 1 h / 80 °C

3: sodium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / ethanol; water; toluene / 1 h / 80 °C

With n-Amyl nitrite; iodine; sodium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In ethanol; chloroform; water; toluene;

Reference yield:

: 873566-75-7
(3-amino-4-fluoro-phenyl)boronic acid

: 1374135-36-0
methyl 5'-[4-({(4S,5R)-5-[3,5-bis(trifluoromethyl)phenyl]-4-methyl-2-oxo-1,3-oxazolidin-3-yl}methyl)-2-(methylsulfanyl)pyrimidin-5-yl]-2'-fluoro-2-methylbiphenyl-4-carboxylate

Guidance literature:: Multi-step reaction with 3 steps

1: sodium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / ethanol; water; toluene / 1 h / 80 °C

2: n-Amyl nitrite; iodine / chloroform / 1 h / 80 °C

3: sodium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / ethanol; water; toluene / 1 h / 80 °C

With n-Amyl nitrite; iodine; sodium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In ethanol; chloroform; water; toluene;