Hexadecanoic acid (R)-1-[benzyloxy-(2-bromo-ethoxy)-phosphoryloxymethyl]-2-trityloxy-ethyl ester

Base Information

Chemical Name:Hexadecanoic acid (R)-1-[benzyloxy-(2-bromo-ethoxy)-phosphoryloxymethyl]-2-trityloxy-ethyl ester
CAS No.:156832-59-6
Molecular Formula:C₄₇H₆₂BrO₇P
Molecular Weight:849.883
Hs Code.:

Synonyms:Hexadecanoic acid (R)-1-[benzyloxy-(2-bromo-ethoxy)-phosphoryloxymethyl]-2-trityloxy-ethyl ester

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Chemical Property of Hexadecanoic acid (R)-1-[benzyloxy-(2-bromo-ethoxy)-phosphoryloxymethyl]-2-trityloxy-ethyl ester

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Technology Process of Hexadecanoic acid (R)-1-[benzyloxy-(2-bromo-ethoxy)-phosphoryloxymethyl]-2-trityloxy-ethyl ester

There total 5 articles about Hexadecanoic acid (R)-1-[benzyloxy-(2-bromo-ethoxy)-phosphoryloxymethyl]-2-trityloxy-ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

: 623-65-4
palmitic anhydride

: 156832-58-5
Phosphoric acid benzyl ester 2-bromo-ethyl ester (R)-2-hydroxy-3-trityloxy-propyl ester

: 156832-59-6
Hexadecanoic acid (R)-1-[benzyloxy-(2-bromo-ethoxy)-phosphoryloxymethyl]-2-trityloxy-ethyl ester

Guidance literature:: With dmap; triethylamine; In tetrahydrofuran; Ambient temperature;
DOI:10.1021/jo00128a043

Reference yield:

: 76-83-5
trityl chloride

: 156832-59-6
Hexadecanoic acid (R)-1-[benzyloxy-(2-bromo-ethoxy)-phosphoryloxymethyl]-2-trityloxy-ethyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: 52 percent / DIPEA / 40 h / Ambient temperature

2: 92 percent / Et₃N, DMAP / tetrahydrofuran / Ambient temperature

With dmap; triethylamine; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran;
DOI:10.1021/jo00128a043

Reference yield:

: 169684-98-4
Phosphorochloridic acid 2-bromo-ethyl ester (R)-2,2-dimethyl-[1,3]dioxolan-4-ylmethyl ester

: 156832-59-6
Hexadecanoic acid (R)-1-[benzyloxy-(2-bromo-ethoxy)-phosphoryloxymethyl]-2-trityloxy-ethyl ester

Guidance literature:: Multi-step reaction with 4 steps

2: 80 percent / 1 M H₃PO₄ / Ambient temperature

3: 52 percent / DIPEA / 40 h / Ambient temperature

4: 92 percent / Et₃N, DMAP / tetrahydrofuran / Ambient temperature

With dmap; phosphoric acid; triethylamine; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran;
DOI:10.1021/jo00128a043