2-(7-fluoro-4-methoxy-1-methyl-5-phenyl-1H-indol-3-yl)-N,N-dimethylacetamide

Base Information

Chemical Name:2-(7-fluoro-4-methoxy-1-methyl-5-phenyl-1H-indol-3-yl)-N,N-dimethylacetamide
CAS No.:1265218-50-5
Molecular Formula:C₂₀H₂₁FN₂O₂
Molecular Weight:340.397
Hs Code.:

Synonyms:2-(7-fluoro-4-methoxy-1-methyl-5-phenyl-1H-indol-3-yl)-N,N-dimethylacetamide

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Chemical Property of 2-(7-fluoro-4-methoxy-1-methyl-5-phenyl-1H-indol-3-yl)-N,N-dimethylacetamide

Chemical Property:

Purity/Quality:

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Technology Process of 2-(7-fluoro-4-methoxy-1-methyl-5-phenyl-1H-indol-3-yl)-N,N-dimethylacetamide

There total 11 articles about 2-(7-fluoro-4-methoxy-1-methyl-5-phenyl-1H-indol-3-yl)-N,N-dimethylacetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1265218-48-1
2-(5-bromo-7-fluoro-4-methoxy-1-methyl-1H-indol-3-yl)-N,N-dimethylacetamide

: 98-80-6
phenylboronic acid

: 1265218-50-5
2-(7-fluoro-4-methoxy-1-methyl-5-phenyl-1H-indol-3-yl)-N,N-dimethylacetamide

Guidance literature:: With caesium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In 1,4-dioxane; Inert atmosphere; Reflux;

Reference yield:

: 344-20-7
2,6-dibromo-4-fluorophenol

: 1265218-50-5
2-(7-fluoro-4-methoxy-1-methyl-5-phenyl-1H-indol-3-yl)-N,N-dimethylacetamide

Guidance literature:: Multi-step reaction with 10 steps

1.1: potassium carbonate / acetone / 6 h / 20 °C

2.1: nitric acid; sulfuric acid / 0 °C

3.1: hydrogenchloride; tin(II) chloride hydrate / ethanol / 20 °C

3.2: pH 6 - 7

4.1: 20 °C

5.1: sodium hydride / tetrahydrofuran; mineral oil / 20 °C

5.2: 20 °C

6.1: N-ethyl-N,N-diisopropylamine; tetrabutylammomium bromide / palladium diacetate / N,N-dimethyl-formamide / 3 h / 80 °C / Inert atmosphere

7.1: potassium hydroxide; water / 1 h / 20 °C / Reflux

7.2: pH 5

8.1: HATU / tetrahydrofuran / 0 °C

8.2: 20 °C

9.1: potassium hydroxide / N,N-dimethyl-formamide / 20 °C

10.1: caesium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,4-dioxane / Inert atmosphere; Reflux

With hydrogenchloride; tin(II) chloride hydrate; sulfuric acid; tetrabutylammomium bromide; water; nitric acid; sodium hydride; potassium carbonate; caesium carbonate; N-ethyl-N,N-diisopropylamine; HATU; potassium hydroxide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; palladium diacetate; In tetrahydrofuran; 1,4-dioxane; ethanol; N,N-dimethyl-formamide; acetone; mineral oil;

Reference yield:

: 371-41-5
4-Fluorophenol

: 1265218-50-5
2-(7-fluoro-4-methoxy-1-methyl-5-phenyl-1H-indol-3-yl)-N,N-dimethylacetamide

Guidance literature:: Multi-step reaction with 11 steps

1.1: bromine / acetic acid / 20 °C

2.1: potassium carbonate / acetone / 6 h / 20 °C

3.1: nitric acid; sulfuric acid / 0 °C

4.1: hydrogenchloride; tin(II) chloride hydrate / ethanol / 20 °C

4.2: pH 6 - 7

5.1: 20 °C

6.1: sodium hydride / tetrahydrofuran; mineral oil / 20 °C

6.2: 20 °C

7.1: N-ethyl-N,N-diisopropylamine; tetrabutylammomium bromide / palladium diacetate / N,N-dimethyl-formamide / 3 h / 80 °C / Inert atmosphere

8.1: potassium hydroxide; water / 1 h / 20 °C / Reflux

8.2: pH 5

9.1: HATU / tetrahydrofuran / 0 °C

9.2: 20 °C

10.1: potassium hydroxide / N,N-dimethyl-formamide / 20 °C

11.1: caesium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,4-dioxane / Inert atmosphere; Reflux

With hydrogenchloride; tin(II) chloride hydrate; sulfuric acid; tetrabutylammomium bromide; water; bromine; nitric acid; sodium hydride; potassium carbonate; caesium carbonate; N-ethyl-N,N-diisopropylamine; HATU; potassium hydroxide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; palladium diacetate; In tetrahydrofuran; 1,4-dioxane; ethanol; acetic acid; N,N-dimethyl-formamide; acetone; mineral oil;