4-chloro-2-hydroxyphenylacetic acid

Base Information

• Chemical Name: 4-chloro-2-hydroxyphenylacetic acid
• CAS No.: 82085-61-8
• Molecular Formula: C8H7 Cl O3
• Molecular Weight: 0
• Mol file: 82085-61-8.mol

Synonyms:4-Chloro-2-hydroxyphenylaceticacid

Chemical Property of 4-chloro-2-hydroxyphenylacetic acid

Chemical Property:

• Vapor Pressure: 1.26E-05mmHg at 25°C
• Boiling Point: 354.1°C at 760 mmHg
• Flash Point: 168°C
• PSA: 57.53000
• Density: 1.466g/cm³
• LogP: 1.67270

Purity/Quality:

99%min ^*data from raw suppliers

4-CHLORO-2-HYDROXYPHENYLACETICACID 97% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 4-chloro-2-hydroxyphenylacetic acid

There total 2 articles about 4-chloro-2-hydroxyphenylacetic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2-(4-chloro-2-methoxyphenyl)acetic acid (170737-95-8) → 2-(4-chloro-2-hydroxy-benzene)acetic acid (82085-61-8)

Guidance literature:

With hydrogen bromide; In acetic acid; for 48h; Heating / reflux;

Reference yield:

→ 2-(4-chloro-2-hydroxy-benzene)acetic acid (82085-61-8)

Guidance literature:

Reference yield:

1-fluoro-4-(methylsulfonyl)-2-(trifluoromethyl)benzene (873194-65-1) + 2-(4-chloro-2-hydroxy-benzene)acetic acid (82085-61-8) → 2-(4-chloro-2-[4-(methylsulfonyl)-2-(trifluoromethyl)phenoxy]-benzene)acetic acid

Guidance literature:

With caesium carbonate; In 1-Methylpyrrolidine; at 80 ℃; for 10h;

upstream raw materials:

2-(4-chloro-2-methoxyphenyl)acetic acid

Refernces

• 1、 -. "Preparation process for hydroxyphenylacetic acids". . . Retrieved 2008/06/13.