(E)-3-(2'-p-chlorophenyl-2'-oxo)ethylidene isobenzofuran-1(3H)-one

Base Information

• Chemical Name: (E)-3-(2'-p-chlorophenyl-2'-oxo)ethylidene isobenzofuran-1(3H)-one
• CAS No.: 77532-15-1
• Molecular Formula: C₁₆H₉ClO₃
• Molecular Weight: 284.699
• Mol file: 77532-15-1.mol

Synonyms:(E)-3-(2'-p-chlorophenyl-2'-oxo)ethylidene isobenzofuran-1(3H)-one

Chemical Property of (E)-3-(2'-p-chlorophenyl-2'-oxo)ethylidene isobenzofuran-1(3H)-one

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (E)-3-(2'-p-chlorophenyl-2'-oxo)ethylidene isobenzofuran-1(3H)-one

There total 6 articles about (E)-3-(2'-p-chlorophenyl-2'-oxo)ethylidene isobenzofuran-1(3H)-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 48.0%

2-[3-hydroxy-3-(p-chlorophenyl)]-prop-1-ynyl benzyl alcohol (399017-11-9) → (E)-3-(2'-p-chlorophenyl-2'-oxo)ethylidene isobenzofuran-1(3H)-one (77532-15-1)

Guidance literature:

With chromium(VI) oxide; sulfuric acid; In water; acetone; at 0 ℃;

DOI:10.1016/S0040-4020(01)00943-7

Reference yield:

phthalic anhydride (85-44-9) → (E)-3-(2'-p-chlorophenyl-2'-oxo)ethylidene isobenzofuran-1(3H)-one (77532-15-1)

Guidance literature:

Multi-step reaction with 2 steps

1: 81 percent / sodium methoxide / xylene / 2 h / 110 - 120 °C

2: SOCl₂ / CHCl₃ / 3 h / Heating

With thionyl chloride; sodium methylate; In chloroform; xylene;

DOI:10.1246/bcsj.61.1791

Reference yield:

para-chloroacetophenone (99-91-2) → (E)-3-(2'-p-chlorophenyl-2'-oxo)ethylidene isobenzofuran-1(3H)-one (77532-15-1)

Guidance literature:

Multi-step reaction with 2 steps

1: 81 percent / sodium methoxide / xylene / 2 h / 110 - 120 °C

2: SOCl₂ / CHCl₃ / 3 h / Heating

With thionyl chloride; sodium methylate; In chloroform; xylene;

DOI:10.1246/bcsj.61.1791

upstream raw materials:

2-<3-(4-Chlorophenyl)-1,3-dioxopropyl>benzoic acid

2-[3-hydroxy-3-(p-chlorophenyl)]-prop-1-ynyl benzyl alcohol

2-iodobenzyl alcohol

1-(4-chlorophenyl)prop-2-yn-1-ol