oxyhydrastinine

Base Information

• Chemical Name: oxyhydrastinine
• CAS No.: 552-29-4
• Molecular Formula: C11H11 N O3
• Molecular Weight: 205.213
• Hs Code.: 2934999090
• Mol file: 552-29-4.mol

Synonyms:Oxyhydrastinine(6CI); 1-Oxohydrastinine; N-Methylnoroxyhydrastinine; Oxyhydrastinin

Chemical Property of oxyhydrastinine

Chemical Property:

• Vapor Pressure: 5.78E-07mmHg at 25°C
• Melting Point: 96-98 °C(Solv: cyclohexane (110-82-7))
• Boiling Point: 411°Cat760mmHg
• PKA: -1.19±0.20(Predicted)
• Flash Point: 202.4°C
• PSA: 38.77000
• Density: 1.324g/cm³
• LogP: 0.98130

Purity/Quality:

≥98% （HPLC） ^*data from raw suppliers

Oxohydrastinine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of oxyhydrastinine

There total 21 articles about oxyhydrastinine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

hydrastinine pseudo-cyanide (66946-63-2) → Oxyhydrastinine (552-29-4)

Guidance literature:

With potassium hydroxide; potassium hexacyanoferrate(III); In ethanol; at 60 ℃; for 1h;

DOI:10.1248/cpb.33.4775

Reference yield: 96.0%

N-methyl-6,7-methylenedioxy-1,2,3,4-tetrahydroisoquinoline (494-55-3) → Oxyhydrastinine (552-29-4)

Guidance literature:

With iodosylbenzene; tetra-(n-butyl)ammonium iodide; In water; acetonitrile; at 20 ℃; for 1h;

DOI:10.1002/1522-2675(200204)85:4<1069::AID-HLCA1069>3.0.CO;2-I

Reference yield: 90.0%

6-methyl[1,3]dioxolo[4,5-g]isoquinolin-5(6H)-one (24880-42-0) → Oxyhydrastinine (552-29-4)

Guidance literature:

With hydrogen; palladium(II) hydroxide; In ethanol; for 24h; Reflux;

DOI:10.1055/s-0033-1341158

upstream raw materials:

hydrastinine

(S)-bulocapnine

N-methyl-13,14-dehydrostylopinium chloride

noroxyhydrastinine

Downstream raw materials:

hydrastinine

C₁₈H₁₄F₃NO₄

C₂₀H₁₉NO₅

C₁₈H₁₇NO₄

Refernces

• 1、 Kim, Junwon,Jo, Mina,So, Wonyoung,No, Zaesung. "Pd-catalyzed ortho-arylation of 3,4-dihydroisoquinolones via C-H bond activation: synthesis of 8-aryl-1,2,3,4-tetrahydroisoquinolines". scheme or table. p. 1229 - 1235. Retrieved 2009/05/27.
• 2、 Lee, Albert, W. M.,Chan, Wing Hong,Chan, Eddy T. T.. "A Facile Total Synthesis of Isoquinolone Alkaloids". . p. 309 - 310. Retrieved 2007/10/02.