ethyl 2-amino-7-hydroxy-4-(3,4-dimethoxyphenyl)-4H-chromene-3-carboxylate

Base Information

Chemical Name:ethyl 2-amino-7-hydroxy-4-(3,4-dimethoxyphenyl)-4H-chromene-3-carboxylate
CAS No.:401464-02-6
Molecular Formula:C₂₀H₂₁NO₆
Molecular Weight:371.39
Hs Code.:

Synonyms:ethyl 2-amino-7-hydroxy-4-(3,4-dimethoxyphenyl)-4H-chromene-3-carboxylate

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of ethyl 2-amino-7-hydroxy-4-(3,4-dimethoxyphenyl)-4H-chromene-3-carboxylate

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Technology Process of ethyl 2-amino-7-hydroxy-4-(3,4-dimethoxyphenyl)-4H-chromene-3-carboxylate

There total 2 articles about ethyl 2-amino-7-hydroxy-4-(3,4-dimethoxyphenyl)-4H-chromene-3-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 2.0%

: 24393-47-3
ethyl (E)-2-cyano-3-(3,4-dimethoxyphenyl)-2-propenoate

: 108-46-3
recorcinol

: 401464-02-6
ethyl 2-amino-7-hydroxy-4-(3,4-dimethoxyphenyl)-4H-chromene-3-carboxylate

Guidance literature:: With piperidine; In ethanol; for 4h; Reflux;
DOI:10.1016/j.bmc.2019.115261

Reference yield:

: 120-14-9
3,4-dimethoxy-benzaldehyde

: 105-56-6
ethyl 2-cyanoacetate

: 401464-02-6
ethyl 2-amino-7-hydroxy-4-(3,4-dimethoxyphenyl)-4H-chromene-3-carboxylate

Guidance literature:: Multi-step reaction with 2 steps

1: piperidine / 4 h / Reflux

2: piperidine / ethanol / 4 h / Reflux

With piperidine; In ethanol; 1: |Knoevenagel Condensation;
DOI:10.1016/j.bmc.2019.115261