(E)-1,2,3,4,5-pentafluoro-6-[3-(4-methoxyphenyl)allyl]benzene

Base Information

• Chemical Name: (E)-1,2,3,4,5-pentafluoro-6-[3-(4-methoxyphenyl)allyl]benzene
• CAS No.: 1289638-89-6
• Molecular Formula: C₁₆H₁₁F₅O
• Molecular Weight: 314.255
• Mol file: 1289638-89-6.mol

Synonyms:(E)-1,2,3,4,5-pentafluoro-6-[3-(4-methoxyphenyl)allyl]benzene

Chemical Property of (E)-1,2,3,4,5-pentafluoro-6-[3-(4-methoxyphenyl)allyl]benzene

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (E)-1,2,3,4,5-pentafluoro-6-[3-(4-methoxyphenyl)allyl]benzene

There total 14 articles about (E)-1,2,3,4,5-pentafluoro-6-[3-(4-methoxyphenyl)allyl]benzene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

Pentafluorobenzene (363-72-4) + (Z)-tert-butyl (3-(4-methoxyphenyl)allyl) carbonate (1314581-29-7) → (E)-1,2,3,4,5-pentafluoro-6-[3-(4-methoxyphenyl)allyl]benzene (1289638-89-6)

Guidance literature:

With copper(l) iodide; 1,10-Phenanthroline; palladium diacetate; caesium carbonate; triphenylphosphine; In toluene; at 120 ℃; for 12h; regioselective reaction; Inert atmosphere;

DOI:10.1002/anie.201008174

Reference yield: 90.0%

tert-butyl (E)-3-(4'-methoxyphenyl)prop-2-en-1-yl carbonate (872672-13-4) + Pentafluorobenzene (363-72-4) → (E)-1,2,3,4,5-pentafluoro-6-[3-(4-methoxyphenyl)allyl]benzene (1289638-89-6)

Guidance literature:

With copper(l) iodide; 1,10-Phenanthroline; palladium diacetate; caesium carbonate; triphenylphosphine; In toluene; at 120 ℃; for 12h; regioselective reaction; Inert atmosphere;

DOI:10.1002/anie.201008174

Reference yield: 88.0%

Pentafluorobenzene (363-72-4) + 1-methoxy-4-(prop-1-yn-1-yl)benzene (2749-94-2) → (E)-1,2,3,4,5-pentafluoro-6-[3-(4-methoxyphenyl)allyl]benzene (1289638-89-6)

Guidance literature:

With dicyclohexyl-(2',6'-dimethoxybiphenyl-2-yl)-phosphane; palladium diacetate; cesium pivalate; In toluene; at 120 ℃; for 18h; regioselective reaction; Schlenk technique; Inert atmosphere; Sealed tube;

DOI:10.1021/acs.orglett.8b00393

upstream raw materials:

Pentafluorobenzene

tert-butyl (E)-3-(4'-methoxyphenyl)prop-2-en-1-yl carbonate

(Z)-tert-butyl (3-(4-methoxyphenyl)allyl) carbonate

4-(4-methoxyphenyl)prop-2-yn-1-ol

Downstream raw materials:

1,2,3,4,5-pentafluoro-6-(3-(4-methoxyphenyl)propyl)benzene