(2S,4S,5S,7S)-5-azido-N-(2,2-dimethyl-3-(4-methylphenylsulfonamido)propyl)-4-hydroxy-2-isopropyl-7-(4-methoxy-3-(3-methoxypropoxy)benzyl)-8-methylnonanamide

Base Information

Chemical Name:(2S,4S,5S,7S)-5-azido-N-(2,2-dimethyl-3-(4-methylphenylsulfonamido)propyl)-4-hydroxy-2-isopropyl-7-(4-methoxy-3-(3-methoxypropoxy)benzyl)-8-methylnonanamide
CAS No.:1321622-45-0
Molecular Formula:C₃₇H₅₉N₅O₇S
Molecular Weight:717.971
Hs Code.:

(2S,4S,5S,7S)-5-azido-N-(2,2-dimethyl-3-(4-methylphenylsulfonamido)propyl)-4-hydroxy-2-isopropyl-7-(4-methoxy-3-(3-methoxypropoxy)benzyl)-8-methylnonanamide

Synonyms:(2S,4S,5S,7S)-5-azido-N-(2,2-dimethyl-3-(4-methylphenylsulfonamido)propyl)-4-hydroxy-2-isopropyl-7-(4-methoxy-3-(3-methoxypropoxy)benzyl)-8-methylnonanamide

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Chemical Property of (2S,4S,5S,7S)-5-azido-N-(2,2-dimethyl-3-(4-methylphenylsulfonamido)propyl)-4-hydroxy-2-isopropyl-7-(4-methoxy-3-(3-methoxypropoxy)benzyl)-8-methylnonanamide

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Technology Process of (2S,4S,5S,7S)-5-azido-N-(2,2-dimethyl-3-(4-methylphenylsulfonamido)propyl)-4-hydroxy-2-isopropyl-7-(4-methoxy-3-(3-methoxypropoxy)benzyl)-8-methylnonanamide

There total 7 articles about (2S,4S,5S,7S)-5-azido-N-(2,2-dimethyl-3-(4-methylphenylsulfonamido)propyl)-4-hydroxy-2-isopropyl-7-(4-methoxy-3-(3-methoxypropoxy)benzyl)-8-methylnonanamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 45.6%

: 1321622-63-2
N-(3-amino-2,2-dimethylpropyl)-4-methylbenzenesulfon-amide

: 1227379-44-3
C₂₅H₃₉N₃O₅

: 1321622-45-0
(2S,4S,5S,7S)-5-azido-N-(2,2-dimethyl-3-(4-methylphenylsulfonamido)propyl)-4-hydroxy-2-isopropyl-7-(4-methoxy-3-(3-methoxypropoxy)benzyl)-8-methylnonanamide

Guidance literature:: With 2-hydroxypyridin; triethylamine; at 65 ℃;
DOI:10.1016/j.bmc.2011.05.059

Reference yield:

: 111992-61-1
2-(3-bromo-2, 2-dimethylpropyl)-2,3-dihydro-1H-isoindole-1,3-dione

: 1321622-45-0
(2S,4S,5S,7S)-5-azido-N-(2,2-dimethyl-3-(4-methylphenylsulfonamido)propyl)-4-hydroxy-2-isopropyl-7-(4-methoxy-3-(3-methoxypropoxy)benzyl)-8-methylnonanamide

Guidance literature:: Multi-step reaction with 5 steps

1: sodium azide / N,N-dimethyl-formamide / 8 h / 100 °C

2: hydrazine hydrate / ethanol / 4 h / 80 °C

3: triethylamine / dichloromethane / 0 - 25 °C

4: palladium 10% on activated carbon; hydrogen / methanol / 25 °C

5: 2-hydroxypyridin; triethylamine / 65 °C

With 2-hydroxypyridin; sodium azide; palladium 10% on activated carbon; hydrogen; hydrazine hydrate; triethylamine; In methanol; ethanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1016/j.bmc.2011.05.059

Reference yield:

: 1321622-79-0
N-(3-azido-2,2-dimethylpropyl)-4-methylbenzenesulfonamide

: 1321622-45-0
(2S,4S,5S,7S)-5-azido-N-(2,2-dimethyl-3-(4-methylphenylsulfonamido)propyl)-4-hydroxy-2-isopropyl-7-(4-methoxy-3-(3-methoxypropoxy)benzyl)-8-methylnonanamide

Guidance literature:: Multi-step reaction with 2 steps

1: palladium 10% on activated carbon; hydrogen / methanol / 25 °C

2: 2-hydroxypyridin; triethylamine / 65 °C

With 2-hydroxypyridin; palladium 10% on activated carbon; hydrogen; triethylamine; In methanol;
DOI:10.1016/j.bmc.2011.05.059