(S)-2-[(R)-1-((R)-1-Methoxycarbonyl-ethylcarbamoyl)-3-methyl-butylcarbamoyl]-pyrrolidine-1-carboxylic acid benzyl ester

Base Information

Chemical Name:(S)-2-[(R)-1-((R)-1-Methoxycarbonyl-ethylcarbamoyl)-3-methyl-butylcarbamoyl]-pyrrolidine-1-carboxylic acid benzyl ester
CAS No.:14811-48-4
Molecular Formula:C₂₃H₃₃N₃O₆
Molecular Weight:447.532
Hs Code.:

Synonyms:(S)-2-[(R)-1-((R)-1-Methoxycarbonyl-ethylcarbamoyl)-3-methyl-butylcarbamoyl]-pyrrolidine-1-carboxylic acid benzyl ester

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Chemical Property of (S)-2-[(R)-1-((R)-1-Methoxycarbonyl-ethylcarbamoyl)-3-methyl-butylcarbamoyl]-pyrrolidine-1-carboxylic acid benzyl ester

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Technology Process of (S)-2-[(R)-1-((R)-1-Methoxycarbonyl-ethylcarbamoyl)-3-methyl-butylcarbamoyl]-pyrrolidine-1-carboxylic acid benzyl ester

There total 3 articles about (S)-2-[(R)-1-((R)-1-Methoxycarbonyl-ethylcarbamoyl)-3-methyl-butylcarbamoyl]-pyrrolidine-1-carboxylic acid benzyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 2026-39-3,53137-69-2
(R)-2-((R)-2-Amino-4-methyl-pentanoylamino)-propionic acid methyl ester; hydrochloride

: 1148-11-4
N-Benzyloxycarbonyl-L-proline

: 14811-48-4
(S)-2-[(R)-1-((R)-1-Methoxycarbonyl-ethylcarbamoyl)-3-methyl-butylcarbamoyl]-pyrrolidine-1-carboxylic acid benzyl ester

Guidance literature:: With benzotriazol-1-ol; triethylamine; dicyclohexyl-carbodiimide; In dichloromethane; N,N-dimethyl-formamide; at 5 ℃; Yield given;
DOI:10.1248/cpb.38.1007

Reference yield:

: 16937-99-8,53296-34-7
Boc-D-Leu-OH

: 14811-48-4
(S)-2-[(R)-1-((R)-1-Methoxycarbonyl-ethylcarbamoyl)-3-methyl-butylcarbamoyl]-pyrrolidine-1-carboxylic acid benzyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: 95 percent / triethylamine (TEA), dicyclohexylcarbodiimide (DCC), N-hydroxybenzotriazole (HOBt) / dimethylformamide; CH₂Cl₂ / 5 °C

2: HCl / ethyl acetate / Ambient temperature

3: triethylamine (TEA), dicyclohexylcarbodiimide (DCC), N-hydroxybenzotriazole (HOBt) / dimethylformamide; CH₂Cl₂ / 5 °C

With hydrogenchloride; benzotriazol-1-ol; triethylamine; dicyclohexyl-carbodiimide; In dichloromethane; ethyl acetate; N,N-dimethyl-formamide;
DOI:10.1248/cpb.38.1007

Reference yield:

: 129585-28-0
(R)-2-((R)-2-tert-Butoxycarbonylamino-4-methyl-pentanoylamino)-propionic acid methyl ester

: 14811-48-4
(S)-2-[(R)-1-((R)-1-Methoxycarbonyl-ethylcarbamoyl)-3-methyl-butylcarbamoyl]-pyrrolidine-1-carboxylic acid benzyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: HCl / ethyl acetate / Ambient temperature

2: triethylamine (TEA), dicyclohexylcarbodiimide (DCC), N-hydroxybenzotriazole (HOBt) / dimethylformamide; CH₂Cl₂ / 5 °C

With hydrogenchloride; benzotriazol-1-ol; triethylamine; dicyclohexyl-carbodiimide; In dichloromethane; ethyl acetate; N,N-dimethyl-formamide;
DOI:10.1248/cpb.38.1007