(3R)-1-(4-tert-butyldimethylsiloxymethylphenyl)-3,4-O-isopropylidene-3,4-dihydroxybutylazide

Base Information

Chemical Name:(3R)-1-(4-tert-butyldimethylsiloxymethylphenyl)-3,4-O-isopropylidene-3,4-dihydroxybutylazide
CAS No.:228267-28-5
Molecular Formula:C₂₀H₃₃N₃O₃Si
Molecular Weight:391.586
Hs Code.:

Synonyms:(3R)-1-(4-tert-butyldimethylsiloxymethylphenyl)-3,4-O-isopropylidene-3,4-dihydroxybutylazide

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Chemical Property of (3R)-1-(4-tert-butyldimethylsiloxymethylphenyl)-3,4-O-isopropylidene-3,4-dihydroxybutylazide

Chemical Property:

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Technology Process of (3R)-1-(4-tert-butyldimethylsiloxymethylphenyl)-3,4-O-isopropylidene-3,4-dihydroxybutylazide

There total 4 articles about (3R)-1-(4-tert-butyldimethylsiloxymethylphenyl)-3,4-O-isopropylidene-3,4-dihydroxybutylazide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 228267-27-4
(3R)-1-(4-tert-butyldimethylsiloxymethylphenyl)-3,4-O-isopropylidene-3,4-dihydroxybutanol

: 228267-28-5
(3R)-1-(4-tert-butyldimethylsiloxymethylphenyl)-3,4-O-isopropylidene-3,4-dihydroxybutylazide

Guidance literature:: With diphenyl-phosphinic acid; triphenylphosphine; diethylazodicarboxylate; In tetrahydrofuran; at 0 ℃;
DOI:10.1016/S0968-0896(00)00125-5

Reference yield:

: methanesulfonic acid 1-[4-(tert-butyl-dimethyl-silanyloxymethyl)-phenyl]-2-(2,2-dimethyl-[1,3]dioxolan-4-yl)-ethyl ester

: 228267-28-5
(3R)-1-(4-tert-butyldimethylsiloxymethylphenyl)-3,4-O-isopropylidene-3,4-dihydroxybutylazide

Guidance literature:: With sodium azide; In N,N-dimethyl-formamide; at 50 ℃;
DOI:10.1016/S0960-894X(99)00657-5

Reference yield:

: 72496-37-8
((R)-2,2-Dimethyl-[1,3]dioxolan-4-yl)-acetaldehyde

: 228267-28-5
(3R)-1-(4-tert-butyldimethylsiloxymethylphenyl)-3,4-O-isopropylidene-3,4-dihydroxybutylazide

Guidance literature:: Multi-step reaction with 2 steps

1: 88.8 percent / n-BuLi / tetrahydrofuran; hexane / -70 °C

2: PPh₃; DEAD; DPPA / tetrahydrofuran / 0 °C

With n-butyllithium; diphenyl-phosphinic acid; triphenylphosphine; diethylazodicarboxylate; In tetrahydrofuran; hexane; 1: Condensation / 2: Substitution;
DOI:10.1016/S0968-0896(00)00125-5