3-mesityl-2-oxopropanoic acid

Base Information

• Chemical Name: 3-mesityl-2-oxopropanoic acid
• CAS No.: 69747-16-6
• Molecular Formula: C₁₂H₁₄O₃
• Molecular Weight: 206.241
• Mol file: 69747-16-6.mol

Synonyms:3-mesityl-2-oxopropanoic acid

Chemical Property of 3-mesityl-2-oxopropanoic acid

Chemical Property:

Purity/Quality:

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MSDS Files:

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Technology Process of 3-mesityl-2-oxopropanoic acid

There total 2 articles about 3-mesityl-2-oxopropanoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

2,4,6-trimethylphenyl bromide (576-83-0) + 1-(4-methyl-2,6,7-trioxabicyclo[2.2.2]octan-1-yl)ethan-1-one → 3-mesityl-2-oxopropanoic acid (69747-16-6)

Guidance literature:

2,4,6-trimethylphenyl bromide; 1-(4-methyl-2,6,7-trioxabicyclo[2.2.2]octan-1-yl)ethan-1-one; With dichloro[1,1'-bis(di-t-butylphosphino)ferrocene]palladium(II); sodium t-butanolate; In tetrahydrofuran; at 50 ℃; for 24h; Inert atmosphere;

With sodium hydrogen sulfate; In tetrahydrofuran; water; at 20 ℃; for 3h; Inert atmosphere;

With lithium hydroxide; In tetrahydrofuran; water; at 20 ℃; for 2h; Inert atmosphere;

DOI:10.1021/acs.orglett.7b02524

Reference yield:

→ 3-mesityl-2-oxopropanoic acid (69747-16-6)

Guidance literature:

entspr. Halgenid, Carbonylierg.;

DOI:10.1039/c39780001090

upstream raw materials:

2,4,6-trimethylphenyl bromide