(R)-2-(3-bromophenyl)-2-methyl-4,4-bis(phenylsulfonyl)butanal

Base Information

• Chemical Name: (R)-2-(3-bromophenyl)-2-methyl-4,4-bis(phenylsulfonyl)butanal
• CAS No.: 1224962-04-2
• Molecular Formula: C₂₃H₂₁BrO₅S₂
• Molecular Weight: 521.453
• Mol file: 1224962-04-2.mol

Synonyms:(R)-2-(3-bromophenyl)-2-methyl-4,4-bis(phenylsulfonyl)butanal

Chemical Property of (R)-2-(3-bromophenyl)-2-methyl-4,4-bis(phenylsulfonyl)butanal

Chemical Property:

Purity/Quality:

Safty Information:

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Technology Process of (R)-2-(3-bromophenyl)-2-methyl-4,4-bis(phenylsulfonyl)butanal

There total 2 articles about (R)-2-(3-bromophenyl)-2-methyl-4,4-bis(phenylsulfonyl)butanal which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

1,1-bis(phenylsulfonyl)ethylene (39082-53-6) + 2-(3-bromophenyl)propanal (59452-90-3) → (R)-2-(3-bromophenyl)-2-methyl-4,4-bis(phenylsulfonyl)butanal (1224962-04-2)

Guidance literature:

With (S)‐N‐(2‐amino‐3‐methylbutyl)perfluorobutanesulfonamide; trifluoroacetic acid; In m-xylene; at 20 ℃; for 4h; enantioselective reaction;

DOI:10.1055/S-0032-1317137

Reference yield:

1,1-bis(phenylsulfonyl)ethylene (39082-53-6) + 2-(3-bromophenyl)propanal (59452-90-3) → (S)-2-(3-bromophenyl)-2-methyl-4,4-bis(phenylsulfonyl)butanal + (R)-2-(3-bromophenyl)-2-methyl-4,4-bis(phenylsulfonyl)butanal (1224962-04-2)

Guidance literature:

With N-((2R,3R)-2-amino-3-(tert-butyldimethylsilyloxy)butyl)trifluoromethanesulfonamide; In p-fluorotoluene; at 20 ℃; for 12h; optical yield given as %ee;

DOI:10.1039/b919549a

upstream raw materials:

1,1-bis(phenylsulfonyl)ethylene

2-(3-bromophenyl)propanal