(2S)-tert-butyl 2-((2S)-1-((2S)-1-hydroxy-3-phenylpropan-2-ylcarbamoyl)-2,2-dimethylpropylcarbamoyl)pyrrolidine-1-carboxylate

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Chemical Name:(2S)-tert-butyl 2-((2S)-1-((2S)-1-hydroxy-3-phenylpropan-2-ylcarbamoyl)-2,2-dimethylpropylcarbamoyl)pyrrolidine-1-carboxylate
CAS No.:1609252-08-5
Molecular Formula:C₂₅H₃₉N₃O₅
Molecular Weight:461.602
Hs Code.:

Synonyms:(2S)-tert-butyl 2-((2S)-1-((2S)-1-hydroxy-3-phenylpropan-2-ylcarbamoyl)-2,2-dimethylpropylcarbamoyl)pyrrolidine-1-carboxylate

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Chemical Property of (2S)-tert-butyl 2-((2S)-1-((2S)-1-hydroxy-3-phenylpropan-2-ylcarbamoyl)-2,2-dimethylpropylcarbamoyl)pyrrolidine-1-carboxylate

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Technology Process of (2S)-tert-butyl 2-((2S)-1-((2S)-1-hydroxy-3-phenylpropan-2-ylcarbamoyl)-2,2-dimethylpropylcarbamoyl)pyrrolidine-1-carboxylate

There total 5 articles about (2S)-tert-butyl 2-((2S)-1-((2S)-1-hydroxy-3-phenylpropan-2-ylcarbamoyl)-2,2-dimethylpropylcarbamoyl)pyrrolidine-1-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 65.0%

: 3182-95-4
L-Phenylalaninol

: 1452777-84-2
(2S)-2-({[(2S)-1-(tert-butoxycarbonyl)pyrrolidin-2-yl]carbonyl}amino)-3,3-dimethylbutanoic acid

: 1609252-08-5
(2S)-tert-butyl 2-((2S)-1-((2S)-1-hydroxy-3-phenylpropan-2-ylcarbamoyl)-2,2-dimethylpropylcarbamoyl)pyrrolidine-1-carboxylate

Guidance literature:: (2S)-2-({[(2S)-1-(tert-butoxycarbonyl)pyrrolidin-2-yl]carbonyl}amino)-3,3-dimethylbutanoic acid; In tetrahydrofuran; butan-1-ol; at 0 ℃; for 0.166667h;

L-Phenylalaninol; With triethylamine; dicyclohexyl-carbodiimide; In tetrahydrofuran; butan-1-ol; at 20 ℃; for 25h;
DOI:10.1016/j.tet.2014.04.016

Reference yield:

: 147-85-3,25191-13-3,37159-97-0,4305-67-3,4607-28-7
L-proline

: 1609252-08-5
(2S)-tert-butyl 2-((2S)-1-((2S)-1-hydroxy-3-phenylpropan-2-ylcarbamoyl)-2,2-dimethylpropylcarbamoyl)pyrrolidine-1-carboxylate

Guidance literature:: Multi-step reaction with 4 steps

1.1: sodium hydroxide / 1,4-dioxane; water / 0 - 20 °C

2.1: tetrahydrofuran; butan-1-ol / 0.17 h / 0 °C

2.2: 25 h / 20 °C

3.1: sodium hydroxide / methanol; water / 27 h / 0 - 20 °C / pH 11

4.1: tetrahydrofuran; butan-1-ol / 0.17 h / 0 °C

4.2: 25 h / 20 °C

With sodium hydroxide; In tetrahydrofuran; 1,4-dioxane; methanol; water; butan-1-ol;
DOI:10.1016/j.tet.2014.04.016

Reference yield:

: 15761-39-4,59433-50-0
1-(tert-butoxycarbonyl)-L-proline

: 1609252-08-5
(2S)-tert-butyl 2-((2S)-1-((2S)-1-hydroxy-3-phenylpropan-2-ylcarbamoyl)-2,2-dimethylpropylcarbamoyl)pyrrolidine-1-carboxylate

Guidance literature:: Multi-step reaction with 3 steps

1.1: tetrahydrofuran; butan-1-ol / 0.17 h / 0 °C

1.2: 25 h / 20 °C

2.1: sodium hydroxide / methanol; water / 27 h / 0 - 20 °C / pH 11

3.1: tetrahydrofuran; butan-1-ol / 0.17 h / 0 °C

3.2: 25 h / 20 °C

With sodium hydroxide; In tetrahydrofuran; methanol; water; butan-1-ol;
DOI:10.1016/j.tet.2014.04.016