Technology Process of (2S,4R)-benzyl 2-(hydroxymethyl)-4-(1-methylcyclobutoxy)pyrrolidine-1-carboxylate
There total 4 articles about (2S,4R)-benzyl 2-(hydroxymethyl)-4-(1-methylcyclobutoxy)pyrrolidine-1-carboxylate which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
(2S,4R)-benzyl 2-((tert-butyldiphenylsilyloxy)methyl)-4-(1-methylcyclobutoxy)pyrrolidine-1-carboxylate;
With
tetrabutyl ammonium fluoride;
In
tetrahydrofuran;
at 20 ℃;
for 60h;
With
water;
In
tetrahydrofuran; ethyl acetate;
- Guidance literature:
-
Multi-step reaction with 4 steps
1: lithium borohydride / tetrahydrofuran / 0 - 20 °C / Inert atmosphere
2: 1H-imidazole / N,N-dimethyl-formamide / 20 °C / Inert atmosphere
3: boron trifluoride diethyl etherate / dichloromethane / 20 °C / Inert atmosphere; Sealed tube
4: tetrabutyl ammonium fluoride / tetrahydrofuran / 60 h / 20 °C
With
1H-imidazole; lithium borohydride; boron trifluoride diethyl etherate; tetrabutyl ammonium fluoride;
In
tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide;
- Guidance literature:
-
Multi-step reaction with 3 steps
1: 1H-imidazole / N,N-dimethyl-formamide / 20 °C / Inert atmosphere
2: boron trifluoride diethyl etherate / dichloromethane / 20 °C / Inert atmosphere; Sealed tube
3: tetrabutyl ammonium fluoride / tetrahydrofuran / 60 h / 20 °C
With
1H-imidazole; boron trifluoride diethyl etherate; tetrabutyl ammonium fluoride;
In
tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide;
