(E)-ethyl 2-(2-(4-chlorophenyl)-1-(phenylsulfonyl)vinyl)-5-methyloxazole-4-carboxylate

Base Information

• Chemical Name: (E)-ethyl 2-(2-(4-chlorophenyl)-1-(phenylsulfonyl)vinyl)-5-methyloxazole-4-carboxylate
• CAS No.: 1198115-59-1
• Molecular Formula: C₂₁H₁₈ClNO₅S
• Molecular Weight: 431.897
• Mol file: 1198115-59-1.mol

Synonyms:(E)-ethyl 2-(2-(4-chlorophenyl)-1-(phenylsulfonyl)vinyl)-5-methyloxazole-4-carboxylate

Chemical Property of (E)-ethyl 2-(2-(4-chlorophenyl)-1-(phenylsulfonyl)vinyl)-5-methyloxazole-4-carboxylate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (E)-ethyl 2-(2-(4-chlorophenyl)-1-(phenylsulfonyl)vinyl)-5-methyloxazole-4-carboxylate

There total 1 articles about (E)-ethyl 2-(2-(4-chlorophenyl)-1-(phenylsulfonyl)vinyl)-5-methyloxazole-4-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

ethyl 5-methyl-2-(phenylsulfonylmethyl)oxazole-4-carboxylate (1155364-03-6) + 4-chlorobenzaldehyde (104-88-1) → (E)-ethyl 2-(2-(4-chlorophenyl)-1-(phenylsulfonyl)vinyl)-5-methyloxazole-4-carboxylate (1198115-59-1)

Guidance literature:

With titanium tetrachloride; triethylamine; In tetrahydrofuran; dichloromethane; at 20 ℃; for 3h; stereoselective reaction; Inert atmosphere;

DOI:10.1021/jo9018705

Reference yield: 91.0%

(E)-ethyl 2-(2-(4-chlorophenyl)-1-(phenylsulfonyl)vinyl)-5-methyloxazole-4-carboxylate (1198115-59-1) → (E)-ethyl 2-(4-chlorostyryl)-5-methyloxazole-4-carboxylate (89723-97-7)

Guidance literature:

With water; ammonium chloride; zinc; In tetrahydrofuran; for 6h; Reflux; Inert atmosphere;

DOI:10.1021/jo9018705

Reference yield:

(E)-ethyl 2-(2-(4-chlorophenyl)-1-(phenylsulfonyl)vinyl)-5-methyloxazole-4-carboxylate (1198115-59-1) → (Z)-ethyl 2-(4-chlorostyryl)-5-methyloxazole-4-carboxylate + (E)-ethyl 2-(4-chlorostyryl)-5-methyloxazole-4-carboxylate (89723-97-7)

Guidance literature:

With water; ammonium chloride; zinc; In tetrahydrofuran; at 20 ℃; for 0.5h; Inert atmosphere;

DOI:10.1021/jo9018705

upstream raw materials:

ethyl 5-methyl-2-(phenylsulfonylmethyl)oxazole-4-carboxylate

4-chlorobenzaldehyde

Downstream raw materials:

(E)-ethyl 2-(4-chlorostyryl)-5-methyloxazole-4-carboxylate