(3-(4-((dimethylamino)methyl)-3-methylphenoxy)azetidin-1-yl)(5-phenyl-1,3,4-oxadiazol-2-yl)methanone

Base Information

• Chemical Name: (3-(4-((dimethylamino)methyl)-3-methylphenoxy)azetidin-1-yl)(5-phenyl-1,3,4-oxadiazol-2-yl)methanone
• CAS No.: 1354791-41-5
• Molecular Formula: C₂₂H₂₄N₄O₃
• Molecular Weight: 392.458
• Mol file: 1354791-41-5.mol

Synonyms:(3-(4-((dimethylamino)methyl)-3-methylphenoxy)azetidin-1-yl)(5-phenyl-1,3,4-oxadiazol-2-yl)methanone

Chemical Property of (3-(4-((dimethylamino)methyl)-3-methylphenoxy)azetidin-1-yl)(5-phenyl-1,3,4-oxadiazol-2-yl)methanone

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (3-(4-((dimethylamino)methyl)-3-methylphenoxy)azetidin-1-yl)(5-phenyl-1,3,4-oxadiazol-2-yl)methanone

There total 4 articles about (3-(4-((dimethylamino)methyl)-3-methylphenoxy)azetidin-1-yl)(5-phenyl-1,3,4-oxadiazol-2-yl)methanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

1-(4-(azetidin-3-yloxy)-2-methylphenyl)-N,N-dimethylmethanamine (1354792-45-2) + ethyl 5-phenyl-1,3,4-oxadiazole-2-carboxylate (16691-25-1) → (3-(4-((dimethylamino)methyl)-3-methylphenoxy)azetidin-1-yl)(5-phenyl-1,3,4-oxadiazol-2-yl)methanone (1354791-41-5)

Guidance literature:

at 120 ℃; for 2h; Sealed tube;

Reference yield:

4-hydroxy-2-methyl-benzaldehyde (41438-18-0) → (3-(4-((dimethylamino)methyl)-3-methylphenoxy)azetidin-1-yl)(5-phenyl-1,3,4-oxadiazol-2-yl)methanone (1354791-41-5)

Guidance literature:

Multi-step reaction with 4 steps

1.1: triethylamine; sodium tris(acetoxy)borohydride / dichloromethane / 20 °C

2.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 1.17 h / Inert atmosphere; Cooling with ice

2.2: 80 °C / Inert atmosphere

3.1: hydrogenchloride; methanol / 20 °C

4.1: 2 h / 120 °C / Sealed tube

With hydrogenchloride; methanol; sodium tris(acetoxy)borohydride; sodium hydride; triethylamine; In dichloromethane; N,N-dimethyl-formamide; mineral oil;

Reference yield:

4-((dimethylamino)methyl)-3-methylphenol (1354792-43-0) → (3-(4-((dimethylamino)methyl)-3-methylphenoxy)azetidin-1-yl)(5-phenyl-1,3,4-oxadiazol-2-yl)methanone (1354791-41-5)

Guidance literature:

Multi-step reaction with 3 steps

1.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 1.17 h / Inert atmosphere; Cooling with ice

1.2: 80 °C / Inert atmosphere

2.1: hydrogenchloride; methanol / 20 °C

3.1: 2 h / 120 °C / Sealed tube

With hydrogenchloride; methanol; sodium hydride; In N,N-dimethyl-formamide; mineral oil;

upstream raw materials:

1-(4-(azetidin-3-yloxy)-2-methylphenyl)-N,N-dimethylmethanamine

ethyl 5-phenyl-1,3,4-oxadiazole-2-carboxylate

4-hydroxy-2-methyl-benzaldehyde

tert-butyl 3-(4-((dimethylamino)methyl)-3-methylphenoxy)azetidine-1-carboxylate